Details

scope
vip-interneurons
claim_text
Previously, loss of the <i>Tsc1</i> gene, which results in hyperactive mTOR, was shown to affect the function and molecular properties of GABAergic cortical interneurons (CINs) derived from the medial ganglionic eminence.
section_id
section_08
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-08-in-vivo-behavior
source_kind
review_finding
source_path
evidence/section_08_evidence_package.json
source_span
Previously, loss of the <i>Tsc1</i> gene, which results in hyperactive mTOR, was shown to affect the function and molecular properties of GABAergic cortical interneurons (CINs) derived from the medial ganglionic eminence.
section_title
In Vivo Function During Behavior
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
unevaluated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-08-in-vivo-behavior
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "doi": "10.3390/cells13010052",
  "pmid": "38201256",
  "tags": [
    "disease_R4"
  ],
  "year": "2023",
  "claim": "Previously, loss of the <i>Tsc1</i> gene, which results in hyperactive mTOR, was shown to affect the function and molecular properties of GABAergic cortical interneurons (CINs) derived from the medial ganglionic eminence.",
  "pmcid": "PMC10777938",
  "round": 4,
  "title": "<i>Tsc1</i> Loss in VIP-Lineage Cortical Interneurons Results in More VIP+ Interneurons and Enhanced Excitability.",
  "authors": "Hu JS, Malik R, Sohal VS, Rubenstein JL, Vogt D.",
  "journal": "",
  "citation": "Hu JS, Malik R, Sohal VS, Rubenstein JL, Vogt D. (2023). . 10.3390/cells13010052",
  "cite_key": "Hu2023",
  "effect_size": null,
  "text_access": "fulltext",
  "citedByCount": 1,
  "isOpenAccess": "Y",
  "evidence_type": "circuit_function",
  "linked_topics": [
    "disinhibition_circuit",
    "disease_models"
  ],
  "_source_cluster": "cluster_07_in_vivo_function",
  "relevance_score": 8.6,
  "replication_status": null,
  "_source_cluster_index": 146,
  "claim_source_sentence": "Previously, loss of the <i>Tsc1</i> gene, which results in hyperactive mTOR, was shown to affect the function and molecular properties of GABAergic cortical interneurons (CINs) derived from the medial ganglionic eminence."
}
source_refs
[
  "paper:paper-0352793d2854"
]
evidence_refs
[
  {
    "ref": "paper:paper-0352793d2854"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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