In mouse C2 barrel column, paired-recording-derived E→E connectivity matrices g…

In mouse C2 barrel column, paired-recording-derived E→E connectivity matrices give differing intracolumnar P(connection) by layer pair: e.g. L4→L2/3 connections form at ~10–15% rate, L2/3→L2/3 at ~10–17%, with strongest unitary EPSP amplitudes for L4→L2/3 and L5→L5 pairs.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2008.12.020",
  "claim": "In mouse C2 barrel column, paired-recording-derived E→E connectivity matrices give differing intracolumnar P(connection) by layer pair: e.g. L4→L2/3 connections form at ~10–15% rate, L2/3→L2/3 at ~10–17%, with strongest unitary EPSP amplitudes for L4→L2/3 and L5→L5 pairs.",
  "cite_key": "Lefort2009",
  "evidence": "Multiple simultaneous whole-cell recordings across all layers of mouse C2 barrel column.",
  "effect_size": "Layer-pair P(conn) matrix in Lefort 2009 reports intra- and translaminar values from ~0% (L4→L6) up to ~17% (L2→L3); strongest unitary EPSPs at L4→L2/3 and L5→L5 (paper figures).",
  "text_access": "abstract_only",
  "study_system": "mouse C2 barrel column, multi-patch paired recordings",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways. The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1371/journal.pbio.1000572",
    "10.7554/eLife.71103",
    "10.1016/j.xinn.2024.100735"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-bdc020492b80"
]

Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways. The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information...

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    "ref": "paper:paper-bdc020492b80"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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