Repeated ventral-hippocampus input stimulation persistently depresses mPFC VIP…

{
  "n": null,
  "doi": "10.1101/2025.07.21.665987",
  "pmid": "",
  "tags": [
    "working_memory"
  ],
  "year": "2025",
  "claim": "Repeated ventral-hippocampus input stimulation persistently depresses mPFC VIP interneuron activity, contributing to spatial working memory plasticity",
  "pmcid": "",
  "round": 2,
  "title": "Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory",
  "journal": "",
  "citation": "Silverstein SE, Clarity TT, Deshpande MS, Vaughan E, Novik S, Yarur HE, Zhang S, Tsai VS, Ye R, Mikofsky RM, Hsiang M, Bauman A, Loewinger G, Pereira F, Morales M, Sohal VS, Tejeda HA, Gordon JA, Kupferschmidt DA.",
  "cite_key": "Silverstein2025",
  "effect_size": null,
  "text_access": "abstract_only",
  "citedByCount": 0,
  "isOpenAccess": "N",
  "evidence_type": "mechanism",
  "linked_topics": [
    "working_memory"
  ],
  "_source_cluster": "cluster_07_in_vivo_function",
  "relevance_score": 0.8,
  "replication_status": null,
  "_source_cluster_index": 66,
  "claim_source_sentence": "<h4>SUMMARY</h4>  Dynamic functional connectivity between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) is essential for spatial working memory (SWM)."
}

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