Complete single-neuron reconstruction of 1,023 pyramidal-tract (PT) and intrate…

Complete single-neuron reconstruction of 1,023 pyramidal-tract (PT) and intratelencephalic (IT) pyramidal neurons across six mouse sensorimotor subregions (MOs, MOp, SSp-ul, SSp-ll) reveals subregion-specific long-range axon collateral patterns of PT cells and distinct IT cortical projection patterns, supporting projection-class- and subregion-specific intracortical wiring.

{
  "n": 1023,
  "doi": "10.34133/research.0470",
  "claim": "Complete single-neuron reconstruction of 1,023 pyramidal-tract (PT) and intratelencephalic (IT) pyramidal neurons across six mouse sensorimotor subregions (MOs, MOp, SSp-ul, SSp-ll) reveals subregion-specific long-range axon collateral patterns of PT cells and distinct IT cortical projection patterns, supporting projection-class- and subregion-specific intracortical wiring.",
  "cite_key": "Yao2024",
  "evidence": "Sparse Cre-driver labeling + fMOST whole-brain imaging of 1,023 individual pyramidal-tract and intratelencephalic neurons in MOs, MOp, SSp-ul, SSp-ll of 70 mouse brains; full axon and dendrite reconstruction; clustering by long-range target combinations.",
  "effect_size": "1,023 reconstructed neurons identify subregion-specific PT projection target patterns (SC/ZI) and distinct IT cortical patterns",
  "text_access": "fulltext",
  "study_system": "mouse sensorimotor cortex (MOs, MOp, SSp), PT and IT pyramidal neurons, sparse labeling + fMOST",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "We acquired the complete morphology of 1,023 pyramidal neurons in the sensorimotor cortex via single-cell reconstruction and performed diverse morphological characterizations of these pyramidal neurons labeled in different subregions.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "By scrutinizing the dominant projection patterns in SC and ZI, we found that PT neurons of different subregions had various projection patterns, which were reflected in the different combinations of the projection targets."
}

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Sparse Cre-driver labeling + fMOST whole-brain imaging of 1,023 individual pyramidal-tract and intratelencephalic neurons in MOs, MOp, SSp-ul, SSp-ll of 70 mouse brains; full axon and dendrite reconstruction; clustering by long-range target combinations.