In mouse motor cortex, recurrent E→E connectivity is organized hierarchically a…

In mouse motor cortex, recurrent E→E connectivity is organized hierarchically and asymmetrically across projection classes: layer-5B corticospinal and corticostriatal/callosal neurons make within-class connections, but across-class connectivity is essentially unidirectional from corticostriatal to corticospinal neurons.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4759-11.2012",
  "claim": "In mouse motor cortex, recurrent E→E connectivity is organized hierarchically and asymmetrically across projection classes: layer-5B corticospinal and corticostriatal/callosal neurons make within-class connections, but across-class connectivity is essentially unidirectional from corticostriatal to corticospinal neurons.",
  "cite_key": "Kiritani2012",
  "evidence": "Paired recordings combined with retrograde labeling and rabies-channelrhodopsin in mouse M1.",
  "effect_size": "Within-class P(conn) corticostriatal > corticospinal; across-class strongly rectified to PT.",
  "text_access": "abstract_only",
  "study_system": "mouse vibrissal M1; layer 5B corticospinal (PT) and corticostriatal/callosal (IT) projection neurons; paired patch + retrograde tracing",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons. In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to corticospinal.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn.2538"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-e1291622a820"
]

Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons. In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to corticospinal.

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    "Local review repositories are read-only inputs.",
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  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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