Details

scope
mouse forelimb M1; rabies-ChR2 + paired recordings
section_id
section_04
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
effect_size
Within-class connection probabilities higher than between-class (hierarchical motif)
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-04-translaminar
source_kind
review_finding
source_path
evidence/section_04_evidence_package.json
source_span
Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connectivity.
study_system
mouse forelimb M1; rabies-ChR2 + paired recordings
section_title
4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
evidence_summary
Optogenetic retrograde rabies-ChR2 stimulation and paired patch recordings of identified corticospinal and corticostriatal L5B neurons in mouse M1 slices.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
consistent with class-specific L5 PT/IT subnetwork organization
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-04-translaminar
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
claim_text
In mouse motor cortex, paired recordings reveal hierarchical excitatory connectivity within layer 5B: corticospinal and callosally projecting corticostriatal neurons form recurrent within-class connections, with biased between-class connectivity defining a corticospinal-corticostriatal microcircuit.
raw_fields
{
  "n": "mouse M1 slices, paired recordings (n in main text)",
  "doi": "10.1523/jneurosci.4759-11.2012",
  "claim": "In mouse motor cortex, paired recordings reveal hierarchical excitatory connectivity within layer 5B: corticospinal and callosally projecting corticostriatal neurons form recurrent within-class connections, with biased between-class connectivity defining a corticospinal-corticostriatal microcircuit.",
  "cite_key": "Kiritani2012",
  "evidence": "Optogenetic retrograde rabies-ChR2 stimulation and paired patch recordings of identified corticospinal and corticostriatal L5B neurons in mouse M1 slices.",
  "effect_size": "Within-class connection probabilities higher than between-class (hierarchical motif)",
  "text_access": "abstract_only",
  "study_system": "mouse forelimb M1; rabies-ChR2 + paired recordings",
  "argument_role": "supporting",
  "replication_status": "consistent with class-specific L5 PT/IT subnetwork organization",
  "claim_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connectivity.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1523/ENEURO.0154-24.2024"
  ],
  "effect_size_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connectivity."
}
source_refs
[
  "paper:paper-e1291622a820"
]
evidence_refs
[
  {
    "ref": "paper:paper-e1291622a820"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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