In mouse motor cortex L5B, optogenetic retrograde rabies-virus-encoded ChR2 plu…

In mouse motor cortex L5B, optogenetic retrograde rabies-virus-encoded ChR2 plus paired recording shows that within-class (recurrent) excitatory connections exist among corticospinal (PT) neurons and among callosally projecting corticostriatal (IT) neurons, but cross-class connectivity is extraordinarily asymmetric and essentially unidirectional from corticostriatal IT to corticospinal PT (IT→PT) — establishing the hierarchical IT→PT motif in mouse M1.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4759-11.2012",
  "claim": "In mouse motor cortex L5B, optogenetic retrograde rabies-virus-encoded ChR2 plus paired recording shows that within-class (recurrent) excitatory connections exist among corticospinal (PT) neurons and among callosally projecting corticostriatal (IT) neurons, but cross-class connectivity is extraordinarily asymmetric and essentially unidirectional from corticostriatal IT to corticospinal PT (IT→PT) — establishing the hierarchical IT→PT motif in mouse M1.",
  "cite_key": "Kiritani2012",
  "evidence": "Retrograde rabies-virus-delivered ChR2 in identified projection classes combined with paired patch-clamp recordings in mouse motor cortex slices.",
  "effect_size": "qualitative — asymmetric, essentially unidirectional IT→PT cross-class connectivity in L5B",
  "text_access": "abstract_only",
  "study_system": "mouse primary motor cortex (M1) layer 5B PT and IT projection neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons. In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to co",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.4023-14.2015",
    "10.1523/JNEUROSCI.4287-14.2015"
  ],
  "effect_size_source_sentence": "across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to co"
}

[
  "paper:paper-e1291622a820"
]

Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons. In contrast, across-class connectivity was extraordinarily asymmetric, essentially unidirectional from corticostriatal to co

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