Long-range monosynaptic inputs to mouse M1 layer-5 deep-output pyramidal neuron…

Long-range monosynaptic inputs to mouse M1 layer-5 deep-output pyramidal neurons concurrently target both apical and basal dendritic compartments, with the dichotomous inputs arising from spatially segregated subpopulations within each upstream area or even within an individual cortical layer.

{
  "n": null,
  "doi": "10.1093/cercor/bhab460",
  "claim": "Long-range monosynaptic inputs to mouse M1 layer-5 deep-output pyramidal neurons concurrently target both apical and basal dendritic compartments, with the dichotomous inputs arising from spatially segregated subpopulations within each upstream area or even within an individual cortical layer.",
  "cite_key": "Geng2022",
  "evidence": "Cre-dependent rabies virus tracing combined with layer-specific chemical retrograde tracing, optogenetic stimulation and electrophysiology of mouse M1 L5 deep-output neurons.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse primary motor cortex layer 5 deep output neurons, rabies + retrograde tracing + sCRACM",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We revealed that most upstream areas innervate both dendritic compartments concurrently... the dichotomous inputs arise mostly from spatially segregated neuronal subpopulations within an upstream nucleus, and even in the case of an individual cortical layer.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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]

We revealed that most upstream areas innervate both dendritic compartments concurrently... the dichotomous inputs arise mostly from spatially segregated neuronal subpopulations within an upstream nucleus, and even in the case of an individual cortical layer.

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