- claim_text
In auditory cortex L1 interneurons (a CGE-derived/VIP-related population) gate the tonotopic critical period via cholinergic (nicotinic) input; developmental upregulation of the nicotinic-modulator Lynx1 closes the period, and overriding Lynx1 keeps it open — providing a molecular handle by which neuromodulation controls plasticity.
- raw_fields
{
"n": null,
"doi": "10.1038/s41593-017-0064-2",
"year": "2018",
"claim": "In auditory cortex L1 interneurons (a CGE-derived/VIP-related population) gate the tonotopic critical period via cholinergic (nicotinic) input; developmental upregulation of the nicotinic-modulator Lynx1 closes the period, and overriding Lynx1 keeps it open — providing a molecular handle by which neuromodulation controls plasticity.",
"title": "Inhibitory circuit gating of auditory critical-period plasticity",
"journal": "",
"species": "mouse",
"cite_key": "Takesian2018",
"evidence": "Optogenetics + cell-type-specific silencing + Lynx1 manipulation in mouse A1.",
"effect_size": "Silencing L1 cells abolished critical-period plasticity; Lynx1 overexpression closed it; loss of Lynx1 kept it open.",
"text_access": "fulltext",
"_source_cluster": "cluster_13_neuromodulation",
"replication_status": "single_study",
"_source_cluster_index": 36,
"claim_source_sentence": "Developmental transitions of nicotinic acetylcholine receptor (nAChR) sensitivity in these cells by the Lynx1 protein can be overridden to extend critical period closure.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Silencing L1 (but not VIP) cells abolishes map plasticity during the tonotopic critical period."
}- source_refs
[
"paper:paper-da0cfdd6fe54"
]
- evidence_refs
[
{
"ref": "paper:paper-da0cfdd6fe54"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}