Layer 1 inhibitory interneurons (but not VIP+ cells) are required for tonotopic…

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scope: mouse primary auditory cortex (A1)
claim_text: Layer 1 inhibitory interneurons (but not VIP+ cells) are required for tonotopic critical-period map plasticity in primary auditory cortex; their nicotinic-acetylcholine sensitivity is gated developmentally by Lynx1.
section_id: section_03
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
effect_size: qualitative — abolition of plasticity by L1 silencing
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-03-development
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: Silencing of L1 (but not VIP-expressing) cells abolishes map plasticity during the tonotopic critical period.
study_system: mouse primary auditory cortex (A1)
section_title: Developmental Origins and Postnatal Maturation
evidence_summary: In vivo silencing experiments and developmental nAChR perturbation in mouse A1.
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-03-development
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/s41593-017-0064-2",
  "claim": "Layer 1 inhibitory interneurons (but not VIP+ cells) are required for tonotopic critical-period map plasticity in primary auditory cortex; their nicotinic-acetylcholine sensitivity is gated developmentally by Lynx1.",
  "title": null,
  "cite_key": "Takesian2018",
  "evidence": "In vivo silencing experiments and developmental nAChR perturbation in mouse A1.",
  "effect_size": "qualitative — abolition of plasticity by L1 silencing",
  "text_access": "abstract_only",
  "study_system": "mouse primary auditory cortex (A1)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 52,
  "claim_source_sentence": "Silencing of L1 (but not VIP-expressing) cells abolishes map plasticity during the tonotopic critical period.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-da0cfdd6fe54"
]

evidence_refs

[
  {
    "ref": "paper:paper-da0cfdd6fe54"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

Layer 1 inhibitory interneurons (but not VIP+ cells) are required for tonotopic…

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