Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD)…

Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons.

{
  "n": null,
  "doi": "10.1111/apha.70162",
  "pmid": "41549331",
  "tags": [
    "disease_R4"
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  "year": "2026",
  "claim": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons.",
  "pmcid": "",
  "round": 4,
  "title": "Non-Hebbian Long-Term Depression at VIP Interneuron Inputs Selectively Tunes Inhibition in Disinhibitory Circuits of Mouse Hippocampus.",
  "authors": "Jabłońska J, Wiera G, Mozrzymas JW.",
  "journal": "",
  "citation": "Jabłońska J, Wiera G, Mozrzymas JW. (2026). . 10.1111/apha.70162",
  "cite_key": "Jabonska2026",
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  "text_access": "abstract_only",
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  "isOpenAccess": "N",
  "evidence_type": "in_vivo_function",
  "linked_topics": [
    "arousal_state",
    "sensory_gain",
    "disinhibition_circuit",
    "prediction_novelty",
    "learning_memory",
    "disease_models",
    "hippocampal_VIP",
    "neuropharmacology"
  ],
  "_source_cluster": "cluster_07_in_vivo_function",
  "relevance_score": 14,
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  "claim_source_sentence": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons."
}

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Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was...

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