Details
- scope
- mouse barrel cortex (S1) L2/3→L5 microcircuit, awake actively sensing
- claim_text
- Optogenetically activating mouse barrel cortex L2/3 pyramidal neurons predominantly suppresses spontaneous L5 activity, and deactivating L2/3 facilitates L5 touch responses — contrary to the canonical L2/3→L5 excitatory feedforward model.
- section_id
- section_02
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-02-anatomy-primer
- source_kind
- review_finding
- source_path
- evidence/section_02_evidence_package.json
- source_span
- Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5.
- study_system
- mouse barrel cortex (S1) L2/3→L5 microcircuit, awake actively sensing
- section_title
- 2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)
- evidence_summary
- Cell-type-specific optogenetic manipulation of L2/3 pyramidal neurons during active whisker sensing in mouse barrel cortex, combined with extracellular L5 recording.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-02-anatomy-primer
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": null, "doi": "10.1523/jneurosci.1459-18.2018", "claim": "Optogenetically activating mouse barrel cortex L2/3 pyramidal neurons predominantly suppresses spontaneous L5 activity, and deactivating L2/3 facilitates L5 touch responses — contrary to the canonical L2/3→L5 excitatory feedforward model.", "cite_key": "Pluta2019", "evidence": "Cell-type-specific optogenetic manipulation of L2/3 pyramidal neurons during active whisker sensing in mouse barrel cortex, combined with extracellular L5 recording.", "effect_size": null, "text_access": "abstract_only", "study_system": "mouse barrel cortex (S1) L2/3→L5 microcircuit, awake actively sensing", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-ec77beb36424" ]
- evidence_refs
[ { "ref": "paper:paper-ec77beb36424" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }