Coordinated Patch-seq and complete-morphology reconstructions of 300 mouse visu…

Coordinated Patch-seq and complete-morphology reconstructions of 300 mouse visual-cortex excitatory neurons define 16 morpho-electric-transcriptomic (MET) types for excitatory cells and demonstrate that transcriptomic variation predicts morphological and electrophysiological phenotype, beginning to link transcriptomic identity to long-range projection targets.

{
  "n": 300,
  "doi": "10.1101/2023.11.25.568393",
  "claim": "Coordinated Patch-seq and complete-morphology reconstructions of 300 mouse visual-cortex excitatory neurons define 16 morpho-electric-transcriptomic (MET) types for excitatory cells and demonstrate that transcriptomic variation predicts morphological and electrophysiological phenotype, beginning to link transcriptomic identity to long-range projection targets.",
  "cite_key": "Sorensen2023",
  "evidence": "First integration of Patch-seq with whole-brain projections for mouse-cortex excitatory cells — directly relevant to cluster_14 anticipated multimodal tooling.",
  "effect_size": "16 MET-types for mouse visual-cortex excitatory cells; 300 reconstructed morphologies",
  "text_access": "abstract_only",
  "study_system": "Mouse visual cortex excitatory neurons; Patch-seq + whole-brain morphology",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "From the Patch-seq data, we defined 16 integrated morphoelectric-transcriptomic (MET)-types; in parallel, we reconstructed the complete morphologies of 300 neurons.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "From the Patch-seq data, we defined 16 integrated morphoelectric-transcriptomic (MET)-types; in parallel, we reconstructed the complete morphologies of 300 neurons."
}

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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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