- claim_text
In mouse mPFC, VIP+ interneurons increase activity in open arms of elevated plus maze and DISINHIBIT prefrontal responses to hippocampal inputs (carrying anxiety information); chemogenetic VIP silencing reduces avoidance behavior — establishing causal VIP→PFC disinhibition role in defensive behavior.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2019.04.001",
"claim": "In mouse mPFC, VIP+ interneurons increase activity in open arms of elevated plus maze and DISINHIBIT prefrontal responses to hippocampal inputs (carrying anxiety information); chemogenetic VIP silencing reduces avoidance behavior — establishing causal VIP→PFC disinhibition role in defensive behavior.",
"title": null,
"cite_key": "Lee2019",
"evidence": "Fiber photometry + chemogenetic silencing of VIP cells + recordings of HC inputs in mouse mPFC during EPM.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse mPFC; in vivo + DREADD",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single-study",
"_source_cluster_index": 77,
"claim_source_sentence": "VIP interneuron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-bec295b7a9a9"
]
- evidence_refs
[
{
"ref": "paper:paper-bec295b7a9a9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}