Details
- scope
- mouse prefrontal cortex, VIP-Cre, EPM
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- VIP interneuron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs, which are known to transmit signals related to open arm avoidance.
- study_system
- mouse prefrontal cortex, VIP-Cre, EPM
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- Abstract: chemogenetic inhibition of VIP+ interneurons during EPM behavior; population-level recordings of hippocampal-prefrontal inputs.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
In mouse prefrontal cortex, VIP interneuron activity increases in the open arms of the elevated plus maze and is required for hippocampal-prefrontal information flow that drives open-arm avoidance; chemogenetic inhibition of VIP interneurons disrupts network representations of open arms and reduces avoidance, showing that VIP-driven disinhibition translates single-cell circuit motifs into anxiety-related behavior.
- raw_fields
{ "n": null, "doi": "10.1016/j.neuron.2019.04.001", "claim": "In mouse prefrontal cortex, VIP interneuron activity increases in the open arms of the elevated plus maze and is required for hippocampal-prefrontal information flow that drives open-arm avoidance; chemogenetic inhibition of VIP interneurons disrupts network representations of open arms and reduces avoidance, showing that VIP-driven disinhibition translates single-cell circuit motifs into anxiety-related behavior.", "title": null, "cite_key": "Lee2019", "evidence": "Abstract: chemogenetic inhibition of VIP+ interneurons during EPM behavior; population-level recordings of hippocampal-prefrontal inputs.", "effect_size": null, "text_access": "abstract_only", "study_system": "mouse prefrontal cortex, VIP-Cre, EPM", "_source_cluster": "cluster_02_development_lineage", "replication_status": "single-study", "_source_cluster_index": 31, "claim_source_sentence": "VIP interneuron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs, which are known to transmit signals related to open arm avoidance.", "replication_evidence_dois": [], "effect_size_source_sentence": "Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal inputs are simultaneously perturbed." }- source_refs
[ "paper:paper-bec295b7a9a9" ]
- evidence_refs
[ { "ref": "paper:paper-bec295b7a9a9" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }