- claim_text
Basal forebrain cholinergic input modulates neocortical activity in a cell-type-specific manner: it preferentially recruits non-pyramidal interneuron subtypes (including VIP) and changes cortical state, providing the canonical framework for cholinergic disinhibition.
- raw_fields
{
"n": null,
"doi": "10.3389/fnsys.2012.00079",
"year": "2012",
"claim": "Basal forebrain cholinergic input modulates neocortical activity in a cell-type-specific manner: it preferentially recruits non-pyramidal interneuron subtypes (including VIP) and changes cortical state, providing the canonical framework for cholinergic disinhibition.",
"title": "Cell-type-specific modulation of neocortical activity by basal forebrain input",
"journal": "",
"species": "multiple",
"cite_key": "Alitto2013",
"evidence": "Review of patch-clamp + in vivo recordings characterizing BF→cortex action.",
"effect_size": "Different interneuron classes show distinct sensitivities to nicotinic vs. muscarinic activation.",
"text_access": "fulltext",
"_source_cluster": "cluster_13_neuromodulation",
"replication_status": "supported",
"_source_cluster_index": 19,
"claim_source_sentence": "Cell-type-specific modulation of neocortical activity by basal forebrain input.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Cholinergic neurons of the basal forebrain target specific subsets of cortical interneurons that in turn shape cortical activity in a cell-type-specific manner."
}- source_refs
[
"paper:paper-b336c49b4f54"
]
- evidence_refs
[
{
"ref": "paper:paper-b336c49b4f54"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}