The MICrONS functional connectomics dataset combines dense calcium imaging of ~…

The MICrONS functional connectomics dataset combines dense calcium imaging of ~75,000 neurons in mouse V1 and higher visual areas with an EM reconstruction of >200,000 cells and 0.5 billion synapses, enabling neuron-resolved structure-function analysis of translaminar and inter-areal cortico-cortical wiring.

{
  "n": 200000,
  "doi": "10.1038/s41586-025-08790-w",
  "claim": "The MICrONS functional connectomics dataset combines dense calcium imaging of ~75,000 neurons in mouse V1 and higher visual areas with an EM reconstruction of >200,000 cells and 0.5 billion synapses, enabling neuron-resolved structure-function analysis of translaminar and inter-areal cortico-cortical wiring.",
  "cite_key": "TheMICrONSConsortium2025",
  "evidence": "MICrONS mouse-cortex EM + functional 2P calcium imaging release.",
  "effect_size": "~75,000 functionally imaged neurons; >200,000 EM-reconstructed cells; 0.5 billion synapses.",
  "text_access": "abstract_only",
  "study_system": "awake mouse visual cortex (VISp, VISrl, VISal, VISlm); MICrONS EM connectome + 2P calcium imaging",
  "argument_role": "supporting",
  "replication_status": "single_study_landmark",
  "claim_source_sentence": "Here we introduce the MICrONS functional connectomics dataset with dense calcium imaging of around 75,000 neurons in primary visual cortex (VISp) and higher visual areas (VISrl, VISal and VISlm) in an awake mouse that is viewing natural and synthetic stimuli. These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses."
}

[
  "paper:paper-aecac0566e4a"
]

Here we introduce the MICrONS functional connectomics dataset with dense calcium imaging of around 75,000 neurons in primary visual cortex (VISp) and higher visual areas (VISrl, VISal and VISlm) in an awake mouse that is viewing natural and synthetic stimuli. These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses.

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