Details

scope
Mouse neocortex; layer L2/3; pyramidal cells
claim_text
A single proofread L2/3 pyramidal cell in VISp had 1,412 output synapses, of which 662 contacted excitatory and 275 contacted inhibitory targets after automated classification.
section_id
section_06
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
effect_size
662 / 1,412 (≈47%) synapses onto excitatory targets
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-06-connectomic-micons
source_kind
review_finding
source_path
evidence/section_06_evidence_package.json
study_system
Mouse neocortex; layer L2/3; pyramidal cells
section_title
6. Connectomic resolution — MICrONS mouse V1/HVA millimetre-scale EM volume; pyramidal-pyramidal wiring statistics derived from it; reconciliation with paired-recording estimates
evidence_summary
Single-cell summary statistics for one MICrONS-proofread L2/3 VISp pyramidal cell.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-06-connectomic-micons
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
raw_fields
{
  "n": 1412,
  "doi": "10.1038/s41586-025-08790-w",
  "claim": "A single proofread L2/3 pyramidal cell in VISp had 1,412 output synapses, of which 662 contacted excitatory and 275 contacted inhibitory targets after automated classification.",
  "cite_key": "TheMICrONSConsortium2025",
  "evidence": "Single-cell summary statistics for one MICrONS-proofread L2/3 VISp pyramidal cell.",
  "effect_size": "662 / 1,412 (≈47%) synapses onto excitatory targets",
  "text_access": "fulltext",
  "study_system": "Mouse neocortex; layer L2/3; pyramidal cells",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "For this particular proofread neuron, 74.5% (1,053 out of 1,412 synapses) are onto objects with a single nucleus (as determined from automated detection), with 275 synapses onto cells classified as inhibitory, 662 synapses onto cells classified as excitatory, and 116 synapses onto cells whose soma did not pass classification quality control (Fig.).",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "For this particular proofread neuron, 74.5% (1,053 out of 1,412 synapses) are onto objects with a single nucleus (as determined from automated detection), with 275 synapses onto cells classified as inhibitory, 662 synapses onto cells classified as excitatory, and 116 synapses onto cells whose soma did not pass classification quality control (Fig.)."
}
source_refs
[
  "paper:paper-aecac0566e4a"
]
source_span
For this particular proofread neuron, 74.5% (1,053 out of 1,412 synapses) are onto objects with a single nucleus (as determined from automated detection), with 275 synapses onto cells classified as inhibitory, 662 synapses onto cells classified as excitatory, and 116 synapses onto cells whose soma did not pass classification quality control (Fig.).
evidence_refs
[
  {
    "ref": "paper:paper-aecac0566e4a"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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