In a mouse model of Dravet syndrome (Scn1a+/−) the irregular-spiking subtype of…

In a mouse model of Dravet syndrome (Scn1a+/−) the irregular-spiking subtype of VIP interneurons shows impaired excitability that is rescued by Nav1.1-specific toxin Hm1a; the IS-vs-CA firing pattern of VIP cells is set by KCNQ M-current and switches to tonic firing on muscarinic receptor activation, demonstrating peptidergic/muscarinic modulation of VIP firing in disease-relevant circuits.

{
  "n": null,
  "doi": "10.7554/elife.46846",
  "year": "2019",
  "claim": "In a mouse model of Dravet syndrome (Scn1a+/−) the irregular-spiking subtype of VIP interneurons shows impaired excitability that is rescued by Nav1.1-specific toxin Hm1a; the IS-vs-CA firing pattern of VIP cells is set by KCNQ M-current and switches to tonic firing on muscarinic receptor activation, demonstrating peptidergic/muscarinic modulation of VIP firing in disease-relevant circuits.",
  "title": "Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome",
  "journal": "",
  "species": "mouse",
  "cite_key": "Goff2019",
  "evidence": "Whole-cell recordings in Scn1a+/− vs. WT slices + pharmacology.",
  "effect_size": "Hm1a rescued IS firing; muscarinic activation converted IS to CA firing.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 35,
  "claim_source_sentence": "IS VIP-INs switched to tonic firing with both pharmacologic blockade of M-current and muscarinic acetylcholine receptor activation.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Application of the Nav1.1-specific toxin Hm1a rescued the observed deficits."
}

[
  "paper:paper-038d4952015c"
]

[
  {
    "ref": "paper:paper-038d4952015c"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}