Cortex–cerebellum dynamics converge during motor learning: cortical L5 and cere…

{
  "n": null,
  "doi": "10.1016/j.cell.2019.02.019",
  "claim": "Cortex–cerebellum dynamics converge during motor learning: cortical L5 and cerebellar GrC populations adopt a shared low-dimensional task-encoding pattern as expertise emerges.",
  "cite_key": "Wagner2019",
  "evidence": "Dual-site two-photon Ca²⁺ imaging in mouse motor cortex L5 and cerebellar GrCs during forelimb task learning.",
  "effect_size": "L5 and GrC correlations approached local correlations within L5",
  "text_access": "abstract_only",
  "study_system": "Mouse forelimb motor task; dual-site two-photon Ca²⁺ imaging of cortical L5 and cerebellar granule cells",
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  "replication_status": "replication_unknown",
  "claim_source_sentence": "Chronic imaging revealed that these dynamics co-emerged in cortex and cerebellum over learning: as behavioral performance improved, initially dissimilar L5 cells and GrCs converged onto a shared, low-dimensional, task-encoding set of neural activity patterns.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": "L5 cells and GrCs shared a common set of task-encoding activity patterns, possessed similar diversity of responses, and exhibited high correlations comparable to local correlations among L5 cells."
}

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Chronic imaging revealed that these dynamics co-emerged in cortex and cerebellum over learning: as behavioral performance improved, initially dissimilar L5 cells and GrCs converged onto a shared, low-dimensional, task-encoding set of neural activity patterns.

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