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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- ADORA2A Gene
ADORA2A — Adenosine A2a Receptor ADORA2A Gene Polymorphism Location 1976C>T 3' UTR -1325G>A Promoter
Read more → - Striatal Output Pathways: Direct, Indirect, and Beyond
Adora2a*-Cre mice, [Cui2013] showed that direct- and indirect-pathway
Read more → - Adenosine A2a Receptor Protein
ADORA2A](https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADORA2A) * [OMIM: ADORA2A](https://www.omim.org/entry/102776) * [IUPHAR
Read more → - Vulnerability, Development, and Individual Differences: Why Not Everyone Becomes Addicted
adora2a* gene expression in NAc and hippocampus — suggesting that substance
Read more → - Betz Cells (Primary Motor Cortex)
ADORA2A["ADORA2A"] -->|"implicated in"| als["als"] ZO1["ZO1"] -->|"implicated in"| als["als"] DDC["DDC"] -->|"implicated
Read more →
Graph neighborhood (30 nodes · 65 edges)
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Related hypotheses
- Adenosine-Astrocyte Metabolic Reset
Reset starts from the claim that modulating ADORA2A within the disease context of neurodegeneration ... molecular underpinnings of adenosine A2A receptor (ADORA2A) modulation in a…
- Parthenolide enhances ADORA2A receptor internalization through direct sesquiterpene lactone-mediated cysteine modification
Parthenolide directly targets ADORA2A receptors through its reactive sesquiterpene lactone moiety, which forms covalent Michael ... receptor internalization and degradation, effec…
- Parthenolide reduces tonic ADORA2A signaling by lowering inflammatory extracellular adenosine tone
programs that sustain extracellular adenosine, indirectly reducing ADORA2A pathway output in mood circuits
- Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A
Covalent modulation of transporters or
- Parthenolide changes ADORA2A coupling efficiency through membrane microdomain remodeling
The scaffold alters receptor signaling
Related debates
- How does parthenolide specifically modulate ADORA2A signaling to produce antidepressant effects?
While the study identifies ADORA2A as a key target through molecular docking and pharmacological validation ... specific mechanism by which parthenolide modulates ADORA2A signalin…