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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Excitotoxicity-Vulnerable Neurons
Excitotoxicity["Excitotoxicity"] -->|"causes"| Neurotoxicity["Neurotoxicity"] Excitotoxicity["Excitotoxicity"] -->|"contributes to"| Ischemic
Read more → - Excitotoxicity Pathway
excitotoxicity["excitotoxicity"] NPY["NPY"] -->|"alleviates"| excitotoxicity["excitotoxicity"] HMGCR["HMGCR"] -.->|"inhibits
Read more → - Excitotoxicity in Neurodegeneration
excitotoxicity["excitotoxicity"] NPY["NPY"] -->|"alleviates"| excitotoxicity["excitotoxicity"] HMGCR["HMGCR"] -.->|"inhibits
Read more → - Excitotoxicity
Excitotoxicity["Excitotoxicity"] -->|"causes"| Neurotoxicity["Neurotoxicity"] Excitotoxicity["Excitotoxicity"] -->|"contributes to"| Stroke
Read more → - Excitotoxicity Comparison Across Neurodegenerative Diseases
excitotoxicity["excitotoxicity"] NPY["NPY"] -->|"alleviates"| excitotoxicity["excitotoxicity"] HMGCR["HMGCR"] -.->|"inhibits
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Related hypotheses
- Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypersynchronized Circuits
Mechanistic Overview Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypersynchronized Circuits starts from ... reads: "## Mechanistic Overview Subtle NM…
- Astrocytic APOE4 Disruption of GABAergic Support Increasing Neuronal Vulnerability
glutamate uptake impairment, extracellular glutamate accumulation, excitotoxicity, and ultimately neuronal TDP-43 vulnerability. That summary ... high-level therapeutic assertion.…
- Mitochondrial Calcium Buffering Enhancement via MCU Modulation
elevation of cytosolic calcium, often resulting from excitotoxicity, impaired calcium extrusion mechanisms, or altered calcium ... with glutamate (100-500 μM) to induce excitotoxi…
- DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization
cytoskeletal dynamics. DAPK1 is activated by excitotoxicity and oxidative stress, phosphorylating substrates like Drp1 (mitochondrial ... Drp1 at Ser616 promoting mitochondrial fi…
- Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutamate Toxicity
stoichiometry, fundamentally linking cellular antioxidant capacity to excitotoxic vulnerability. In the context of ALS pathophysiology ... overload and cytochrome c release. The r…