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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- NPC2 — NPC Intracellular Cholesterol Transporter 2
cholesterol trafficking: - **Cholesterol binding**: Hydrophobic pocket binds cholesterol - **Handoff to NPC1
Read more → - Lipid Metabolism Dysregulation in Neurodegeneration
Cholesterol synthesis regulation | Cholesterol dysregulation | | [LXR](/genes/nr1h3) (LXRA) | Cholesterol efflux
Read more → - Cerebral Cholesterol Metabolism
cholesterol acyltransferase prevent cholesterol esterification, promoting free cholesterol availability and ABCA1
Read more → - ABCG1 Gene
Cholesterol Synthesis"] --> B["Neuronal Cholesterol"] B --> C{"ABCG1 Function"} C --> D["Cholesterol
Read more → - ABCA1 - ATP-Binding Cassette Transporter A1
Cholesterol_Efflux["Cholesterol Efflux"] ABCA1 -->|"mediates"| Cholesterol_Efflux cholesterol_homeostasis
Read more →
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Related hypotheses
- Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Mechanistic Overview Cholesterol-CRISPR Convergence Therapy for Neurodegeneration starts from the claim that modulating HMGCR ... target lies in the brain's unique cholesterol met…
- Membrane Cholesterol Gradient Modulators
Mechanistic Overview Membrane Cholesterol Gradient Modulators starts from the claim that modulating ABCA1/LDLR/SREBF2 within ... relevant process. The original description reads: …
- CYP46A1 Small Molecule Activator Therapy
treat Alzheimer's disease through enhanced brain cholesterol metabolism. Small molecule activators specifically target ... Mechanistically, pharmacological activation provides tem…
- CYP46A1 Overexpression Gene Therapy
Alzheimer's Disease** **Overview and Rationale** Cholesterol homeostasis in the brain is a critical factor ... Unlike peripheral tissues, the brain maintains autonomous cholestero…
- CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalling in Neurodegeneration
neurodegeneration by disrupting the pathological link between cholesterol dysregulation and eIF2α phosphorylation-mediated translation stalling ... Elevated brain cholesterol in n…