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SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.

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Related hypotheses

  • VCP-Mediated Autophagy Enhancement

    particularly tauopathies such as Alzheimer's disease, frontotemporal dementia, and chronic traumatic encephalopathy, the accumulation ... body myopathy with Paget's disease and fr…

  • Lysosomal Membrane Repair Enhancement

    Alzheimer's disease, including Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis ... mutations (particularly R191Q and Q165X) cause familial frontote…

  • Early Proteasome Restoration Therapy

    Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. In 5xFAD mice, which develop aggressive ... tissue. The tau P301S mouse model of frontotemporal dementia re…

  • Cross-Seeding Prevention Strategy

    diseases to include amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and chronic traumatic encephalopathy ... accumulation occurs in ~97% of ALS cases - **Front…

  • Heat Shock Protein 70 Disaggregase Amplification

    cases and 45% of frontotemporal dementia cases, represents a particularly compelling target for HSP70 amplification ... consistently impaired in Alzheimer's disease and frontotemp…

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