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SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Synapse Elimination in Neurodegeneration
Synapse Elimination in Neurodegeneration ## Pathway Diagram ```mermaid flowchart TD N0["SYNAPSE
Read more → - Complement-Mediated Synapse Loss
Synapse Loss ## Overview **Complement-mediated synapse loss** is a pathological
Read more → - microglial-synaptic-pruning-dysregulation
synapses[@cunningham2013]. During brain development, synaptic pruning eliminates approximately 50% of synapses
Read more → - Validated Hypothesis: SASP-Mediated Complement Cascade Amplification
Synapses"] E --> F["Microglial Phagocytosis of Tagged Synapses"] F --> G["Synapse
Read more → - Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics
synapse formation and the assembly of axo-axonic inhibitory synapses
Read more →
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Related hypotheses
- SASP-Mediated Complement Cascade Amplification
zones of complement activation that "tag" healthy synapses for elimination by microglia through a process ... specifically within senescent cell microenvironments could prevent sy…
- Synaptic Pruning Precision Therapy
This pathological pruning disproportionately targets functionally important synapses, contributing to cognitive decline and progressive neurological ... function as "eat-me" signa…
- Complement C1QA Spatial Gradient in Cortical Layers
C1QB, and C1QC subunits) binds to tagged synapses. In the developing brain, this process ... synaptic pruning — C1q marks weak or redundant synapses for elimination by microglia. …
- Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection
membrane attack complex, while simultaneously tagging synapses and neuronal structures for elimination through opsonization ... interconnected pathways. First, PV interneurons for…
- SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs Calcium Sensing and Links Synaptic Dysfunction to SASP-Complement Activation
hippocampus, temporal cortex, and thalamus. C1q tags synapses for microglial pruning during development ... deposition correlating with cognitive decline. C1q-tagged synapses are …