Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

open gaps

#	Title	Status	Priority	Domain	Created
1	How do different exercise modalities (cardiovascular vs resistance) differentia… The review notes that exerkine levels vary by exercise type and duration, but the mechanistic basis for designing individualized exercise programs remains uncle… gap-pubmed-20260410-181117-f0284bf6	open	0.810	neuroplasticity	2026-04-10	Open →
2	What molecular mechanisms link multimodal exercise to BDNF upregulation and cyt… The study shows exercise improves BDNF levels and modulates inflammatory cytokines in AD patients, but the cellular and molecular pathways mediating these chang… gap-pubmed-20260410-183829-a7ef8cea	open	0.800	neuroplasticity	2026-04-10	Open →
3	What specific mechanisms link electroacupuncture's diverse molecular effects to… The study shows EA affects multiple pathways (neurotransmitters, inflammation, oxidative stress, neuroplasticity) but doesn't explain how these diverse molecula… gap-pubmed-20260411-073402-8d257312	open	0.800	neuroplasticity	2026-04-11	Open →
4	What are the specific molecular mechanisms by which exercise preconditioning co… The abstract identifies that exercise creates stress resilience and mentions general pathways (neurotrophic factors, synaptic plasticity, reduced inflammation),… gap-pubmed-20260411-075329-07c88c79	open	0.800	neuroplasticity	2026-04-11	Open →
5	What specific brain plasticity mechanisms underlie MRI-detected structural chan… The abstract identifies neuroanatomical changes in first-time mothers but explicitly states uncertainty about which plasticity mechanisms drive these structural… gap-pubmed-20260410-181311-e63b1eb5	open	0.770	neuroplasticity	2026-04-10	Open →
6	What mechanisms drive cognitive recovery after stroke and how can they be valid… The authors highlight the need for improved insights into recovery mechanisms and validated biomarkers. This knowledge gap limits ability to predict recovery tr… gap-pubmed-20260410-174157-fe2935bd	open	0.750	neuroplasticity	2026-04-10	Open →

for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "research_gap",
    "sort": "priority_score_desc",
    "limit": 50
  }
}