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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

24
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Sequestratio…
molecular neurobiology 10 ev
h-bc351274
METTL3, YTHDF2, lncRNA-0021 (m6A-modified)proposed0.7692026-05-16Open →
2Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mm…
molecular neurobiology 5 ev
h-110fecd1f6
lncRNA-0021proposed0.6702026-05-14Open →
3Gamma-Entrained PV Interneuron Networks Enable Precision p-tau217-Guided lncRNA…
molecular neurobiology 7 ev
h-var-5900d71273
PVALB, CREB1, lncRNA-0021/lncRNA-9969promoted0.5502026-05-14Open →
4A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking…
molecular neurobiology 5 ev
h-49112ee4c0
lncRNA-0021proposed0.5502026-05-14Open →
5Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncR…
molecular neurobiology 7 ev
h-var-297004b1d7
lncRNA-0021, PVALB, CREB1promoted0.5472026-05-14Open →
6Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Del…
molecular neurobiology 7 ev
h-var-99256f9f61
CSF p-tau217 (biomarker), lncRNA-0021, astrocyte-derived extracellular vesiclespromoted0.5422026-05-16Open →
7Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic W…
molecular neurobiology 7 ev
h-var-3049fa9ae4
CSF NFL (biomarker), lncRNA-0021, synthetic liposomespromoted0.5172026-05-16Open →
8Transcriptome-wide competition determines functional selectivity after direct b…
molecular neurobiology 5 ev
h-098b03f430
mmu-miR-6361proposed0.5092026-05-14Open →
9RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex
molecular neurobiology 5 ev
h-df4e435ebf
TARDBP/FUS/HNRNPA2B1proposed0.4972026-05-14Open →
10Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome…
molecular neurobiology 7 ev
h-var-387b2bc276
PVALB, lncRNA-0021promoted0.4642026-05-16Open →
11Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through…
molecular neurobiology 9 ev
h-var-adc924c2d4
SST, CREB1, lncRNA-9969, neuronal autophagy pathwayproposed0.4602026-05-16Open →
12CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle De…
molecular neurobiology 7 ev
h-var-c261b9d0cd
CSF neurofilament light chain (NfL), lncRNA-0021, astrocyte-derived extracellular vesiclespromoted0.4582026-05-16Open →
13CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes ln…
molecular neurobiology 7 ev
h-var-ac595654ef
CSF neurofilament light (biomarker), lncRNA-0021, astrocyte-derived exosomespromoted0.4502026-05-16Open →
14Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial…
molecular neurobiology 9 ev
h-var-981a915d51
SST, CREB1, lncRNA-9969, PGC1α, TFAM, NRF1proposed0.4342026-05-16Open →
15Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therap…
molecular neurobiology 7 ev
h-var-38b7c84a38
lncRNA-9969promoted0.4312026-05-16Open →
16Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochondrial Biogenesis Th…
molecular neurobiology 9 ev
h-var-5c4b90eeeb
SST, CREB1, NRF1, lncRNA-9969, PGC1α, TFAMproposed0.4242026-05-16Open →
17Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Mediated Autophagy Thro…
molecular neurobiology 9 ev
h-var-b0b78b7090
SST, CREB1, lncRNA-9969, neuronal autophagy pathwayproposed0.4212026-05-16Open →
18A-to-I RNA editing modulates the lncRNA-0021 binding site and tunes mmu-miR-636…
molecular neurobiology 5 ev
h-e27562cbb4
ADAR1/ADAR2proposed0.3872026-05-14Open →
19Competitive endogenous RNA mechanism enables lncRNA-0021 to modulate mmu-miR-63…
molecular neurobiology 5 ev
h-var-829523e5d2
lncRNA-0021proposed0.3802026-05-16Open →
20Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial…
molecular neurobiology 14 ev
h-var-288308c7dc
SST, CREB1, lncRNA-9969, PGC1A, TFAMproposed0.3802026-05-16Open →
21CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through Dual Seed-Structur…
molecular neurobiology 5 ev
h-var-08fd0f5a54
lncRNA-9969proposed0.3802026-05-16Open →
22Theta-Gamma Cross-Frequency Coupling Modulates lncRNA-9969 Phase-Dependent Tran…
molecular neurobiology 9 ev
h-var-80aad0dc7c
SST, FMRP, lncRNA-9969, ULK1proposed0.3802026-05-16Open →
23CREB1-Induced lncRNA-9969 Selectively Sequesters miR-6361 Through Dual Seed-Str…
molecular neurobiology 5 ev
h-var-074f135782
lncRNA-9969, CREB1, PVALBproposed0.3802026-05-16Open →
24Competitive endogenous RNA network modulates mmu-miR-6361 availability through…
molecular neurobiology 5 ev
h-var-39780e4efa
lncRNA-0021proposed0.3802026-05-16Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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