Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network

Neuron 2021 156 cites
2021:102022:192023:262024:322025:342026:35
2021 2026
156

Whitesell, Jennifer D. and Liska, Adam and Coletta, Ludovico and Hirokawa, Karla E. and Bohn, Phillip and Williford, Ali and Groblewski, Peter A. and Graddis, Nile and Kuan, Leonard and Knox, Joseph E. and Ho, Anh and Wakeman, Wayne and Nicovich, Philip R. and Nguyen, Thuc Nghi and van Velthoven, Cindy T.J. and Garren, Emma and Fong, Olivia and Naeemi, Maitham and Henry, Alex M. and Dee, Nick and Smith, Kimberly A. and Levi, Boaz and Feng, David and Ng, Lydia and Tasic, Bosiljka and Zeng, Hongkui and Mihalas, Stefan and Gozzi, Alessandro and Harris, Julie A.

Abstract

The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain disorders. How disease affects the DMN is unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity to investigate structural connectivity of the DMN across spatial scales with cell-type resolution. We co-registered maps from functional magnetic resonance imaging and axonal tracing experiments into the 3D Allen mouse brain reference atlas. We find that the mouse DMN consists of preferentially interconnected cortical regions. As a population, DMN layer 2/3 (L2/3) neurons project almost exclusively to other DMN regions, whereas L5 neurons project in and out of the DMN. In the retrosplenial cortex, a core DMN region, we identify two L5 projection types differentiated by in- or out-DMN targets, laminar position, and gene expression. These results provide a multi-scale description of the anatomical correlates of the mouse DMN.

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