Browsing all papers, sorted by Most cited. Showing 8 of 39,449.
Activation of stimulator of interferon genes (STING) and inhibition of vascular…
The cGAS-STING signaling pathway is a crucial innate immune pathway that senses cytosolic DNA. Pharmacological activation of the cGAS-STING pathway might be a promising strategy for cancer immunotherapy. Here, we report that the cGAS-STING pathway is a new target of telatinib, an orally available vascular endothelial growth factor receptor 2 (VEGFR2) inhibit…
AnimalsMembrane ProteinsHumansVascular Endothelial Growth Factor Receptor-2cGAS-STING and PANoptosis: Interplay, Underlying Mechanisms, and Therapeutic Ta…
The cGAS-STING pathway is an essential cytosolic DNA sensing mechanism that activates innate immune responses upon detection of microbial or aberrant self-DNA. This evolutionarily conserved signaling axis plays critical roles in autoimmune diseases, sterile inflammation, and cellular senescence. While its transient activation provides protective immunity, dy…
HumansNucleotidyltransferasesMembrane ProteinsAnimalsAxonal injury is a targetable driver of glioblastoma progression.
Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour1,2. Although advanced disease has been intensely investigated, the mechanisms that underpin the earlier, likely more tractable, stages of GBM development remain poorly understood. Here we identify axonal injury as a key driver of GBM progression, which we find is induced in white m…
["Glioblastoma""Animals""Disease Progression""Mice"Binding and complement activation by C-reactive protein via the collagen-like r…
Ligand-complexed C-reactive protein (CRP), like aggregated or complexed IgG, can react with C1q and activate the classical C pathway. Whereas IgG is known to bind to the globular region and not to the collagen-like region (CLR) of C1q, the site of interaction of C1q with CRP has not been defined. CRP-trimers were prepared by cross-linking and found to bind t…
Microglia.
Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in mechanisms of innate and adaptive immuni…
["Animals""Central Nervous System""Encephalitis""Gliosis"The cGAS-STING signaling pathway: A central regulator and novel therapeutic tar…
The cGAS-STING signaling pathway is a central component of the innate immune system. Skeletal muscle, the body's largest metabolic and endocrine organ, is essential for overall health, and maintaining its homeostasis is critically important. This review systematically elaborates on the central position and "double-edged sword" role of the cGAS-STING pathway…
HumansNucleotidyltransferasesMembrane ProteinsSignal TransductionInhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic s…
NAD is a metabolite that is an important cofactor and second messenger for a number of cellular processes such as genomic stability and metabolism that are essential for survival. NAD is generated de novo from tryptophan or recycled from NAM through the NAMPT-dependent salvage pathway. Alternatively, cells can convert NA to NAD through the NAPRT1-dependent s…
First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PA…
KPT-9274, a potentially first-in-class, dual NAMPT/PAK4 inhibitor, has shown single-agent anticancer activity in hematologic and solid tumor cell lines and xenografts. KPT-9274 has shown anti-tumor activity in combination with nivolumab in nonclinical models. KCP-9274-901 was a first-in-human, multi-center, open-label clinical study to assess preliminary saf…