25 results for “Cellular Proteostasis”. Showing 25 of 39,449.
PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.
cellular proteostasis of endogenous ataxin-3 (Atx3), a protein that
The Mitochondrial F-box protein 1 and DJ-1 homolog HSP31 support cellular proteostasis during mitochondrial protein import clogging.
understand how these mutations affect cellular proteostasis and cause neurodegeneration.
Molecular chaperones mediated proteostasis depletion: A cause of neurodegeneration?
cellular chaperones and other quality control elements, such as ubiquitin-proteasome system and autophagy, form a network, critical for proteostasis
How autophagy can restore proteostasis defects in multiple diseases?
cellular proteostasis that may get perturbed due to the accumulation
CHIP and aging: a key regulator of proteostasis and cellular senescence.
proteostasis, mitochondrial function, and cellular stress resistance results in a build
A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
cellular proteostasis through its involvement in the ubiquitin proteasome system
Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo.
cellular proteostasis. It orchestrates protein turnover and quality control in vivo
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
cellular proteostasis, including increased protein chaperone levels. However, the exact
Visualization of autophagic structures near solid polyQ aggregates reveals how they undermine autophagy.
cellular proteostasis and macroautophagy/autophagy has been proposed to be an important
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation.
cellular proteostasis through aberrant stress granule formation is implicated in neurodegenerative
Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice.
cellular proteostasis due to the failure of the ubiquitin proteasome
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy
E3 ligase recruitment by UBQLN2 protects substrates from proteasomal degradation.
cellular proteostasis that are also linked to several neurodegenerative diseases
Neuropeptide Y at the crossroads of neurodegeneration: Mechanistic insights and emerging therapeutic strategies.
cellular survival, proteostasis, and inflammation and thereby influence disease trajectories
High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS).
Disrupted proteome homeostasis (proteostasis) in amyotrophic lateral sclerosis (ALS) has
Proteostasis in neurodegenerative diseases.
Proteostasis is essential for normal function of proteins and vital for cellular
Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases.
cellular metabolism and proteostasis, reactive oxygen species (ROS) production, and increased
Ubiquilin-2 differentially regulates polyglutamine disease proteins.
cellular pathways of proteostasis. Studies suggest, for example, that the ubiquitin
Targeting the hallmarks of aging: mechanisms and therapeutic opportunities.
proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity.
proteostasis will lead to cellular cytotoxicity and even cell death
Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases.
cellular repair, and proteostasis. In recent years, the gaseous molecule
Ageing as a risk factor for neurodegenerative disease.
proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell
LRRK2 at the Crossroad of Aging and Parkinson's Disease.
cellular functions, including redox imbalance, mitochondria dysfunction, and impaired proteostasis
Carbonic Anhydrase 3 Overexpression Modulates Signalling Pathways Associated with Cellular Stress Resilience and Proteostasis.
Carbonic anhydrase 3 (CA3) exhibits low enzymatic activity compared to
Heat shock response and autophagy--cooperation and control.
proteostasis. Both the direct cellular data on heat shock control