25 results for “Environmental Neurotoxicity”. Showing 25 of 39,449.
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP+ PD model.
strategy for PD induced by environmental neurotoxic pollutants in relation to MPTP.
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
environmental neurotoxicity and suggest that SARM1 agonists could be developed
Lycopene ameliorates Di-(2-ethylhexyl) phthalate-induced neurotoxicity in mice via the gut-brain axis.
neurotoxic risk through environmental and dietary exposure. Growing evidence highlights
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
neurotoxic consequences of acute exposures to environmental agents and drugs
Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking.
environmental pollutant toxicity and gives theoretical basis for elaborating the LiCl-induced neurotoxicity
Single-cell transcriptomics unveils atrazine's impact on neurons and microglia in C57BL/6 mice.
neurotoxic mechanisms remain unclear. This study investigates how environmentally relevant
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.
neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors
Food-grade TiO2/TDCPP Co-exposure disrupts ACOD1/itaconate axis and is associated with TET2-NF-κB inflammation in microglia exacerbating neurotoxicity.
environmental pollutants with high exposure among children, which pose potential risks to neurodevelopment. However, the neurotoxicity
Assessing the Neurotoxicity of Bisphenol A Using Network Toxicology, Molecular Docking, and Molecular Dynamics Simulation.
environmental endocrine disruptor with potential impacts to the neurological system in humans. This study used an integrated method combining network toxicology, molecular docking, and molecular dynamics simulations to explore
Impact of nanoplastics on Alzheimer 's disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity.
neurotoxicity, presenting a valuable foundation for future research on the intricate interplay between environmental
Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations.
environmental concerns due to their widespread pollution and detrimental effects on physiological functions. However, the neurotoxic
Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo.
environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity
Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain.
The role of environmental contaminants in causing Parkinson's disease
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
Environmental toxins are considered the main etiological factor. The increasing use of polystyrene nanoparticles (PS-NPs) has raised concerns about their potential neurotoxic
Unveiling Potential Neurotoxic Mechansisms: Pb-Induced Activation of CDK5-p25 Signaling Axis in Alzheimer's Disease Development, Emphasizing CDK5 Inhibition and Formation of Toxic p25 Species.
environmental factors. Heavy metals, such as lead (Pb), have been implicated in AD pathogenesis, but the underlying mechanisms remain poorly understood. This study investigates the potential neurodegenerative role
SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux.
neurotoxic contaminant that induces cognitive decline similar to that observed in Alzheimer's disease (AD). Autophagic flux dysfunction is attributed to the pathogenesis of AD, and this study aimed
The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging.
environmental, and lifestyle factors. Notably, physical activity has been identified as a potent intervention that enhances neuroplasticity and metabolic resilience while mitigating the effects of neurodegeneration. Research indicates that exercise
Linking particulate matter exposure and neurological disorders: Evidence from epidemiology, biomarkers and mechanistic studies.
environmental determinant of neurological disorders, including Alzheimer's and Parkinson's diseases, neurodevelopmental impairments, and cognitive decline. This review integrates evidence from 129 research articles (2002-2025) to elucidate
Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain.
environmental toxicity, and particularly inflammation, represent prominent etiological factors in PD development. Especially, reactive astrocytes, microglial cells, and infiltrating monocyte-derived macrophages play dual beneficial/harmful effects, via a panel
Role of Ten eleven translocation-2 (Tet2) in modulating neuronal morphology and cognition in a mouse model of Alzheimer's disease.
Environmental Engineering, Qinghai University, Xining, Qinghai, PR China. (4)Faculty of Physical Education, Ningbo University, Ningbo, Zhejiang, PR China. Abnormal expression of Ten eleven translocation-2 (Tet2) contributes
The synergistic effects of UV-328 and polystyrene microplastics on zebrafish embryos: developmental toxicity, oxidative stress, and neurotoxicity.
neurotoxic effects were partially attenuated at higher concentrations of UV-328. The mechanism might involve upregulation of the Gap43 gene and activation of the mTOR signaling pathway. This study
The Minderoo-Monaco Commission on Plastics and Human Health.
environmental impacts of plastic pollution occur at multiple levels from molecular and biochemical to population and ecosystem. MNP contamination of seafood results in direct, though not well quantified, human exposure
Role of Reactive Astrocytes and Microglia: Wnt/β-Catenin Signaling in Neuroprotection and Repair in Parkinson's Disease.
environmental factors acts as a critical modulator of neuronal vulnerability. Strong evidence points to glial reactivity as a central element in PD pathophysiology; however, it remains a controversial topic whether
Tracing the threads: How toxic metals contribute to neurodegeneration.
environmental exposures on biological systems, this review highlights the role of heavy metals (particularly lead, mercury, vanadium, and chromium) in altering behaviour and contributing to the development of neurodegenerative
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis.
neurotoxic species causing cell death in PD. However, the heterogeneous and unstable nature of these oligomers limit their detailed characterization. α-Syn fibrils, on the contrary, are shown