25 results for “metabolic neuroscience”. Showing 25 of 39,449.
Lipid Droplets and Neurodegeneration.
metabolism in the brain has been considered one of the critical research areas of neuroscience
Clearance mechanisms of the glymphatic/lymphatic system in the brain: new therapeutic perspectives for cognitive impairment.
neuroscience in recent years. As the "waste clearance network" of the central nervous system, it clears metabolic
A brain-to-gut signal controls intestinal fat absorption.
Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, SJTUSM, Shanghai, China. (3)Clinical Neuroscience
Hypocretins (orexins): The ultimate translational neuropeptides.
neuroscience findings suggest that the Hcrt system is a hub that integrates diverse inputs modulating arousal (e.g., circadian rhythms, metabolic
A spatially-resolved human brain proteome atlas for understanding function and disease
metabolism, protein homeostasis and therapeutic targets including the seizure-associated purinergic receptor P2RX7. This resource bridges molecular and systems neuroscience
Dynamic changes in the structure and function of brain mural cells around chronically implanted microelectrodes.
neuroscience questions and combat neurological disorders. However, implantation of intracortical devices provokes severe tissue inflammation within the brain, which requires a high metabolic
Dynamic changes in structure and function of brain mural cells around chronically implanted microelectrodes.
neuroscience questions and combat neurological disorders. However, implantation of intracortical devices provokes severe tissue inflammation within the brain, which requires a high metabolic
Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.
neuroscience that studies the influence of various aspects of nutrition (nutrients, diet, eating behavior, food environment, etc.) on the development of nervous disorders and includes nutrition, clinical dietetics, and neurology
Sleep Drives Metabolite Clearance from the Adult Brain
Neurosci. 2013 Dec;14(12):816-7. doi: 10.1038/nrn3632. Nat Rev Neurol. 2013 Dec;9(12):657. doi: 10.1038/nrneurol.2013.230. Mov Disord. 2014 Jan;29(1):33. doi: 10.1002
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
metabolism. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.devcel.2023.07.001 PMCID: PMC10530302 PMID: 37494933 [Indexed for MEDLINE] Conflict of interest statement: Declaration of interests J.A.O
Pharmacogenetics of anxiety and depression in Alzheimer's disease.
Neuroscience & Genomic Medicine, EuroEspes Biomedical Research Center, Bergondo, Corunna, 15165, Spain. Anxiety and depression coexist with cognitive impairment in Alzheimer's disease along with other concomitant disorders (>60%), which require
Mitochondrial dysfunction in Alzheimer's disease.
neuroscience. Early clinical manifestations, such as memory retrieval deficits and apathy, underscore the need for a deeper understanding of the disease's underlying mechanisms. While amyloid-β plaques
Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.
Neuroscience, Mayo Clinic, Jacksonville, FL. Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer's disease (AD), especially late
Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice.
neuroscience and sleep research, potential effects of the DREADD actuator clozapine-N-oxide (CNO) on sleep have never been systematically tested. Here, we show that intraperitoneal injections of commonly used
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension.
Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA. (4)Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. (5)Department of Pediatric Cardiology
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons.
Neuroscience, King's College London, London SE1 1UL, UK; Medical Research Council Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK. Electronic address: oscar.marin@kcl.ac.uk. Cortical neurons
Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents.
Neuroscience and Cell Biology, Coimbra, Portugal. (3)University of Coimbra, Faculty of Pharmacy, Coimbra, Portugal; University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research, Coimbra, Portugal. (4)University
10.3389/fncel.2025.1669272
neuroscience, highlighting selected studies that delineate the roles of reactive microglia and astrocytes in the contexts of developmental inflammatory stress, neurodegenerative diseases, and cellular senescence. Since the characterization of disease
Behavioral neuroscience in zebrafish: unravelling the complexity of brain-behavior relationships.
This paper reviews the utility of zebrafish (Danio rerio) as
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.
Neuroscience, Mayo Clinic, Jacksonville, FL, USA. bu.guojun@mayo.edu. Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan. (6)PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan. (7)Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National
Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease
neuroscience in recent years offer new hope for those suffering from this debilitating disease. There is a unique set of challenges that face researchers when considering how to approach therapeutic
Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics.
Neuroscience and Genomic Medicine, Bergondo, Spain. Atremorine is a novel bioproduct obtained by nondenaturing biotechnological processes from a genetic species of Vicia faba. Atremorine is a potent dopamine (DA) enhancer
Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges.
Neuroscience (A.H.R., D.P.D.W., A.T.S., U.G.) and Department of Drug Design and Pharmacology (C.M.F., J.T.A.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark gether@sund.ku.dk andreass@sund.ku.dk. For more than
The multifaceted role of mitochondria in autism spectrum disorder.
metabolism, greatly contributes to ASD. The aberrant functioning of this organelle is of such high importance that ASD has been proposed as a mitochondrial disease. It should be noted that