TREM2 Variant Design v1 — Wild-type Reference

{
  "method": "AlphaFold2 structure prediction",
  "_origin": {
    "url": null,
    "type": "internal",
    "tracked_at": "2026-04-16T11:11:49.478757"
  },
  "sequence": "MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLN",
  "uniprot_id": "Q9NZC2",
  "binding_affinity": {
    "Kd_nM": 450,
    "target": "phospholipid membrane"
  },
  "predicted_stability": -42.3
}