TREM2 Variant Design v3 — R186K/D87N/T96I Triple Mutant (Optimized)

Details

sequence: MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLNR186K_D87N_T96I
target_protein: phospholipid membrane
score: 0.87
method: RoseTTAFold + Bayesian optimization + MD simulation

Raw fields (1)

metadata

{
  "method": "RoseTTAFold + Bayesian optimization + MD simulation",
  "_origin": {
    "url": null,
    "type": "internal",
    "tracked_at": "2026-04-16T11:11:49.523003"
  },
  "sequence": "MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLNR186K_D87N_T96I",
  "mutations": [
    "R186K",
    "D87N",
    "T96I"
  ],
  "uniprot_id": "Q9NZC2",
  "binding_affinity": {
    "Kd_nM": 120,
    "target": "phospholipid membrane",
    "improvement_fold": 3.75
  },
  "predicted_stability": -47.8
}

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