TREM2 Variant Design v2 — R186K/D87N Dual Mutant

{
  "method": "RoseTTAFold + guided mutagenesis",
  "_origin": {
    "url": null,
    "type": "internal",
    "tracked_at": "2026-04-16T11:11:49.502721"
  },
  "sequence": "MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLNR186K_D87N",
  "mutations": [
    "R186K",
    "D87N"
  ],
  "uniprot_id": "Q9NZC2",
  "binding_affinity": {
    "Kd_nM": 280,
    "target": "phospholipid membrane"
  },
  "predicted_stability": -45.1
}