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All 6 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 0 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Wiki Validated Hypothesis: SASP-Mediated Complement Cascade Amplification rel 9.60

complement—they create localized "complement storms" with concentrations 100-1000x higher

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Wiki Validated Hypothesis: Complement Cascade Inhibition Synaptic Protection rel 5.60

Complement Cascade Inhibition Synaptic Protection Mechanism of Action The complement

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Wiki Validated Hypothesis: Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46) rel 4.70

complement regulation. Biomarker-guided patient selection utilizes CSF complement profiles

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Wiki Validated Hypothesis: Senescent Cell ASM-Complement Cascade Intervention rel 2.80

Complement Cascade Intervention > **Status**: ✅ Validated | **Composite Score**: 0.8520 (85th

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Wiki Validated Hypothesis: CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control rel 1.90

complement vulnerability. This activity-dependent complement regulator positioning enables precise

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Wiki Validated Hypothesis: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds rel 1.80

complement activation. This duality suggests that cell-type-specific vulnerability

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Wiki Validated Hypothesis: Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization rel 1.70

complement regulators CD55 and CD46 to synaptic surfaces represents a dynamic

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Paper Genetic Insights into the Impact of Complement in Alzheimer's Disease. rel 1.30

complement in disease aetiology. Genetic variations in complement genes are widespread

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Wiki Molecular Identity and Transcriptomic Taxonomy rel 1.30

complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal

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Paper Innate immunity and brain inflammation: the key role of complement. rel 1.10

Complement fragments (opsonins; C1q, C3b and iC3b) interact with complement

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Wiki Immune Atlas: Neuroinflammation Analysis rel 1.10

complement cascade, APOE date: 2026-04-24 task_id: d16-06-3DD3879C

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Paper The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. rel 1.00

complement system is responsible for our defense against pathogens. The complement

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Wiki Species Differences and Human Disease rel 1.00

Complement and ApoE now sit at the centre of astrocyte

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Paper Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma. rel 0.90

complement system, immune cells, and mediators of inflammation provides an efficient

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Paper The complement system and human autoimmune diseases. rel 0.70

complement activation pathway (especially C1q, r, s, and C4) are the strongest

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Wiki Composite Claim: Ceramide Rheostats Convert Senescence and Lipid Stress into Neuroimmune Damage rel 0.70

complement models connect acid sphingomyelinase to complement-amplified tissue damage

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Wiki Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing) rel 0.70

complementation in starter cells, restricts retrograde transsynaptic spread to a single

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Paper Synaptic pruning genes networks in Alzheimer's disease: correlations with neuropathology and cognitive decline. rel 0.60

complement system components (C1QA, C1QB, C1QC, C1S, C1R, C3), microglial

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Paper The classical complement cascade mediates CNS synapse elimination. rel 0.60

complement protein C1q or the downstream complement protein C3 exhibit

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Wiki Validated Hypothesis: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration rel 0.60

complement-mediated synaptic loss by binding to complement C1q during

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Paper A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. rel 0.50

complement activation, in producing the necrotizing demyelination seen in the spinal

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Paper HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. rel 0.50

complement deposition on synapses followed by microglial engulfment has been

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Paper Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS). rel 0.40

complement pathway secondary to a not well-understood trigger event

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Paper Free radicals upregulate complement expression in rabbit isolated heart. rel 0.40

complement activation can injure tissue. Our study determined whether free

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Paper Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood-brain barrier. rel 0.40

Complement is increasingly recognized as a context-dependent contributor to cerebral

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Paper 10.1038/nature18283 rel 0.40

complement cascade, a key component of innate immune pathogen defence

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Wiki Regional Diversity of Astrocytes rel 0.40

complement, not a calibrated regional gradient: forebrain regions (cortex, hi... - [shigetomi

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Wiki Hippocampal SST Interneurons rel 0.40

Complementing these cell-type-specific studies, [Takacs2024] characterized the synaptic

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Wiki ALZHEIMER rel 0.40

Complement components C1q and C3, deposited on weakened synapses, recruit

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Paper The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody. rel 0.30

Complement deposition is present in all active white matter lesions

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