← causal

Upstream targets

Entities that most often appear as the source end of a causal edge in substrate_causal_effects. The more mechanisms flow out of an entity, the more upstream it is. Companion view: /targets.

  1. #1 P2RY12 gene 4 edges 1 strategy
  2. #2 TDP-43 nuclear loss-of-function mechanism 4 edges 1 strategy
  3. #3 Piezo1 gene 3 edges 1 strategy
  4. #4 TUBB3 gene 3 edges 1 strategy
  5. #5 mitochondrial dysfunction mechanism 3 edges 1 strategy
  6. #6 α-synuclein aggregation pathology 3 edges 1 strategy
  7. #7 Ecm Stiffness pathway 3 edges 1 strategy
  8. #8 Prmt1-Dependent Methylation process 3 edges 1 strategy
  9. #9 Netrin-1-Engineered Endothelial Cell Exosomes cell 2 edges 1 strategy
  10. #10 Lysosomal dysfunction cellular_mechanism 2 edges 1 strategy
  11. #11 Mitochondrial dysfunction cellular_mechanism 2 edges 1 strategy
  12. #12 Neuroinflammation cellular_mechanism 2 edges 1 strategy
  13. #13 Oxidative stress cellular_mechanism 2 edges 1 strategy
  14. #14 oleuropein chemical 2 edges 1 strategy
  15. #15 Mct8 Deficiency condition 2 edges 1 strategy
  16. #16 dexamethasone drug 2 edges 1 strategy
  17. #17 NP137 drug 2 edges 1 strategy
  18. #18 Epsins gene 2 edges 1 strategy
  19. #19 Hexokinase 2 gene 2 edges 1 strategy
  20. #20 RUBCN gene 2 edges 1 strategy
  21. #21 GBA1 loss-of-function genetic_risk 2 edges 1 strategy
  22. #22 PRKN loss-of-function genetic_risk 2 edges 1 strategy
  23. #23 CD8+ T cell recruitment mechanism 2 edges 1 strategy
  24. #24 multiplexed base editing mechanism 2 edges 1 strategy
  25. #25 oligodendrocyte sulfatide deficiency mechanism 2 edges 1 strategy
  26. #26 TDP-43 cytoplasmic aggregation mechanism 2 edges 1 strategy
  27. #27 UNC13A cryptic exon inclusion molecular_event 2 edges 1 strategy
  28. #28 Mtca2+ Uptake process 2 edges 1 strategy
  29. #29 ACE enhancement protein 2 edges 1 strategy
  30. #30 amyloid-β oligomers protein 2 edges 1 strategy
  31. #31 CaMKII protein 2 edges 1 strategy
  32. #32 cGAS protein 2 edges 1 strategy
  33. #33 H3K18la protein_modification 2 edges 1 strategy
  34. #34 APOE4 variant 2 edges 1 strategy
  35. #35 aging-activated microglia cell_type 1 edge 1 strategy
  36. #36 VIP interneuron stimulation cell_type 1 edge 1 strategy
  37. #37 Axon terminal degeneration cellular_phenotype 1 edge 1 strategy
  38. #38 DA neuron vulnerability cellular_phenotype 1 edge 1 strategy
  39. #39 motor neuron axon retraction cellular_phenotype 1 edge 1 strategy
  40. #40 synaptic vesicle release failure cellular_phenotype 1 edge 1 strategy
  41. #41 α-synuclein propagation cellular_process 1 edge 1 strategy
  42. #42 ox-LDL chemical 1 edge 1 strategy
  43. #43 Polyunsaturated Fatty Acid-Containing Phospholipids chemical 1 edge 1 strategy
  44. #44 puerarin compound 1 edge 1 strategy
  45. #45 Chronic Cerebral Hypoperfusion condition 1 edge 1 strategy
  46. #46 Alzheimer's_disease disease 1 edge 1 strategy
  47. #47 Obstructive Sleep Apnea Syndrome disease 1 edge 1 strategy
  48. #48 DA neuron apoptosis disease_phenotype 1 edge 1 strategy
  49. #49 Prostate Cancer disease 1 edge 1 strategy
  50. #50 27-hydroxycholesterol drug 1 edge 1 strategy
Showing 50 of 100 entities (180 distinct sources tracked corpus-wide).