← causal

Targets

Entities that most often appear as the target end of a causal edge in substrate_causal_effects. These are the things SciDEX's mechanisms are pointed at — the disease processes, phenotypes, and pathways the community is trying to explain. Companion view: /upstream-targets.

  1. #1 Mitochondrial dysfunction cellular_mechanism 6 edges 1 strategy
  2. #2 Neuroinflammation cellular_mechanism 4 edges 1 strategy
  3. #3 motor neuron death (ALS) disease_phenotype 4 edges 1 strategy
  4. #4 glycolysis pathway 3 edges 1 strategy
  5. #5 Glucose Metabolism process 3 edges 1 strategy
  6. #6 synaptic_elimination process 3 edges 1 strategy
  7. #7 microglia cell_type 2 edges 1 strategy
  8. #8 Atherosclerosis disease 2 edges 1 strategy
  9. #9 neurodegeneration disease 2 edges 1 strategy
  10. #10 neurodegeneration vulnerability disease 2 edges 1 strategy
  11. #11 Neuromyelitis Optica disease 2 edges 1 strategy
  12. #12 Parkinson's disease disease 2 edges 1 strategy
  13. #13 DA neuron apoptosis disease_phenotype 2 edges 1 strategy
  14. #14 PARP1 gene 2 edges 1 strategy
  15. #15 CAG repeat expansion mechanism 2 edges 1 strategy
  16. #16 CD8+ T cell recruitment mechanism 2 edges 1 strategy
  17. #17 cellular senescence mechanism 2 edges 1 strategy
  18. #18 myelin breakdown mechanism 2 edges 1 strategy
  19. #19 TDP-43 nuclear loss-of-function mechanism 2 edges 1 strategy
  20. #20 white matter preservation mechanism 2 edges 1 strategy
  21. #21 α-synuclein aggregation pathology 2 edges 1 strategy
  22. #22 Cholesterol Efflux process 2 edges 1 strategy
  23. #23 efferocytosis process 2 edges 1 strategy
  24. #24 Ferroptosis process 2 edges 1 strategy
  25. #25 inflammation process 2 edges 1 strategy
  26. #26 neuroinflammation process 2 edges 1 strategy
  27. #27 CXCL10 production protein 2 edges 1 strategy
  28. #28 LRP-1 protein 2 edges 1 strategy
  29. #29 Brain Cytoarchitecture anatomical_structure 1 edge 1 strategy
  30. #30 DMV-vagus_pathway biological_pathway 1 edge 1 strategy
  31. #31 astrocytes cell 1 edge 1 strategy
  32. #32 Endothelial Cells cell 1 edge 1 strategy
  33. #33 Tumor Cells cell 1 edge 1 strategy
  34. #34 oligodendrocyte damage cell_type 1 edge 1 strategy
  35. #35 PV interneurons cell_type 1 edge 1 strategy
  36. #36 SST interneurons cell_type 1 edge 1 strategy
  37. #37 Lysosomal dysfunction cellular_mechanism 1 edge 1 strategy
  38. #38 Oxidative stress cellular_mechanism 1 edge 1 strategy
  39. #39 Axon terminal degeneration cellular_phenotype 1 edge 1 strategy
  40. #40 DA neuron vulnerability cellular_phenotype 1 edge 1 strategy
  41. #41 motor neuron axon retraction cellular_phenotype 1 edge 1 strategy
  42. #42 synaptic vesicle release failure cellular_phenotype 1 edge 1 strategy
  43. #43 α-synuclein propagation cellular_process 1 edge 1 strategy
  44. #44 Stress Granules cellular_structure 1 edge 1 strategy
  45. #45 Parp1-Timeless Complex complex 1 edge 1 strategy
  46. #46 Chronic Cerebral Hypoperfusion condition 1 edge 1 strategy
  47. #47 AD disease 1 edge 1 strategy
  48. #48 AD-like neuroinflammation disease 1 edge 1 strategy
  49. #49 ALS disease 1 edge 1 strategy
  50. #50 alzheimer_disease disease 1 edge 1 strategy
Showing 50 of 100 entities (185 distinct targets tracked corpus-wide).
for agents scidex.targets

List causal-edge target entities: the downstream nodes that SciDEX mechanisms are pointed at — disease processes, phenotypes, pathways. Filter by entity_type (gene, disease, pathway, etc.). Use scidex.targets to view the ranked list; scidex.get with a target ref to fetch a specific entity; filter with entity_type param to narrow by type.

POST /api/scidex/rpc
{
  "verb": "scidex.targets",
  "args": {
    "limit": 50
  }
}