← causal

Upstream targets

Entities that most often appear as the source end of a causal edge in substrate_causal_effects. The more mechanisms flow out of an entity, the more upstream it is. Companion view: /targets.

  1. #1 TDP-43 nuclear loss-of-function mechanism 4 edges 1 strategy
  2. #2 mitochondrial dysfunction mechanism 3 edges 1 strategy
  3. #3 CD8+ T cell recruitment mechanism 2 edges 1 strategy
  4. #4 multiplexed base editing mechanism 2 edges 1 strategy
  5. #5 oligodendrocyte sulfatide deficiency mechanism 2 edges 1 strategy
  6. #6 TDP-43 cytoplasmic aggregation mechanism 2 edges 1 strategy
  7. #7 aging mechanism 1 edge 1 strategy
  8. #8 AP1S1 downregulation mechanism 1 edge 1 strategy
  9. #9 APOE4 overexpression mechanism 1 edge 1 strategy
  10. #10 APOE4 removal mechanism 1 edge 1 strategy
  11. #11 astrocyte-derived inflammatory signals mechanism 1 edge 1 strategy
  12. #12 astrocyte-specific APOE4 knockout mechanism 1 edge 1 strategy
  13. #13 autophagy upregulation mechanism 1 edge 1 strategy
  14. #14 brain-derived exosomes from aged mice mechanism 1 edge 1 strategy
  15. #15 CAG repeat expansion reduction mechanism 1 edge 1 strategy
  16. #16 cellular senescence mechanism 1 edge 1 strategy
  17. #17 chronic hypoperfusion mechanism 1 edge 1 strategy
  18. #18 complement activation mechanism 1 edge 1 strategy
  19. #19 complex I deficiency mechanism 1 edge 1 strategy
  20. #20 CRISPRa with chromatin modifiers mechanism 1 edge 1 strategy
  21. #21 CRISPRi downregulation of MSH3 mechanism 1 edge 1 strategy
  22. #22 cytokine secretion mechanism 1 edge 1 strategy
  23. #23 cytoskeletal checkpoint disruption mechanism 1 edge 1 strategy
Showing 23 of 23 matching "mechanism" (180 distinct sources tracked corpus-wide).