Introduction: what "excitatory recurrence" means operationally in mouse cortex

Introduction: what “excitatory recurrence” means operationally in mouse cortex

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Citation anchors captured: 35

Citation contexts

• ^{1Citationpaper:paper-bdc020492b80This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference} This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...

• ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference} The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference, 10Citationpaper:paper-e4f11964cdc5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}. These classes are accessed...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1. These classes are accessed...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3. These classes are accessed...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5. These classes are accessed...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7. These classes are accessed...

• ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{2Citationpaper:paper-a80aa5d68f45This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9. These classes are accessed...

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0 The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1. These classes are accessed...

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2 The first is to bracket inhibition. Mouse cortex is not an excitatory-only system. Local inhibition stabilises the recurrent excitatory network and equalises the excitation–inhibition ratio across pyramidal cells by dense, broadly tuned coverage rather than fixed pairwise matching, contributes to lateral suppression along the horizontal axis of L2/3 ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3, and helps set network oscillatory state through la...

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4 The third is to bracket clinical framings. This review treats E→E circuit logic as a basic-research construct. Where a manipulation in mouse links a defined recurrent circuit to a defined behavioural readout — for example the chemogenetic IT activation in ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5 — that work is read on its own terms; clinical implications are not back-fitted onto it.

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8. Patch-seq joins patch electr...

• ^{3Citationpaper:paper-20192df165b8This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1. Patch-seq joins patch electr...

• ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4. Patch-seq joins patch electr...

• ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7. Patch-seq joins patch electr...

• ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{4Citationpaper:paper-3afbd6d3d64fThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0. Patch-seq joins patch electr...

• ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3. Patch-seq joins patch electr...

• ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6. Patch-seq joins patch electr...

• ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{5Citationpaper:paper-bb5df5f7b66eThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9. Patch-seq joins patch electr...

• ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0 The dissection toolkit has matured to the point where single-method idiosyncrasies can usually be checked against an orthogonal measurement. ChR2-axon photostimulation reads out monosynaptic input onto identified postsynaptic targets ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1, and laser-scanning photostimulation across slice yields the presynaptic-to-postsynaptic excitatory matrix of a cortical column ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2. Patch-seq joins patch electr...

• ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3 The first movement — sections 2 through 8 — builds the empirical foundation outward from the highest-resolution wiring evidence. {ref}sec-anatomy-primer supplies the areal map, laminar reference frame, projection-class taxonomy, and tool inventory (paired patch, sCRACM, Cre-controlled rabies tracing ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4, optogenetics ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5, dense EM) that the rest of the review depends on. {ref}`sec-paired-recor...

• ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6 The first movement — sections 2 through 8 — builds the empirical foundation outward from the highest-resolution wiring evidence. {ref}sec-anatomy-primer supplies the areal map, laminar reference frame, projection-class taxonomy, and tool inventory (paired patch, sCRACM, Cre-controlled rabies tracing ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7, optogenetics ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8, dense EM) that the rest of the review depends on. {ref}`sec-paired-recor...

• ^{6Citationpaper:041efce6-fc13-4416-8aca-e196f82f3d70This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9 The first movement — sections 2 through 8 — builds the empirical foundation outward from the highest-resolution wiring evidence. {ref}sec-anatomy-primer supplies the areal map, laminar reference frame, projection-class taxonomy, and tool inventory (paired patch, sCRACM, Cre-controlled rabies tracing ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0, optogenetics ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1, dense EM) that the rest of the review depends on. {ref}`sec-paired-recor...

• ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2 The first movement — sections 2 through 8 — builds the empirical foundation outward from the highest-resolution wiring evidence. {ref}sec-anatomy-primer supplies the areal map, laminar reference frame, projection-class taxonomy, and tool inventory (paired patch, sCRACM, Cre-controlled rabies tracing ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3, optogenetics ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4, dense EM) that the rest of the review depends on. {ref}`sec-paired-recor...

• ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5 A worked example will recur. The Ntsr1-Cre line provides genetic access to L6 corticothalamic neurons and was characterised as a projection-class identifier with high specificity ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6. Awake recordings, however, split the Ntsr1-Cre+ population into sensory-activated and sensory-suppressed channels in V1 ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7, into whisking-modulated and non-modulated subsets in S1 ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8, and...

• ^{7Citationpaper:paper-1bafe87bf289This review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9 A worked example will recur. The Ntsr1-Cre line provides genetic access to L6 corticothalamic neurons and was characterised as a projection-class identifier with high specificity ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}0. Awake recordings, however, split the Ntsr1-Cre+ population into sensory-activated and sensory-suppressed channels in V1 ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}1, into whisking-modulated and non-modulated subsets in S1 ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}2, and...

• ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}3 A worked example will recur. The Ntsr1-Cre line provides genetic access to L6 corticothalamic neurons and was characterised as a projection-class identifier with high specificity ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}4. Awake recordings, however, split the Ntsr1-Cre+ population into sensory-activated and sensory-suppressed channels in V1 ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}5, into whisking-modulated and non-modulated subsets in S1 ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}6, and...

• ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}7 A worked example will recur. The Ntsr1-Cre line provides genetic access to L6 corticothalamic neurons and was characterised as a projection-class identifier with high specificity ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}8. Awake recordings, however, split the Ntsr1-Cre+ population into sensory-activated and sensory-suppressed channels in V1 ^{8Citationpaper:paper-236d0f50c2ddThis review asks one circumscribed question of the mouse-cortex empirical literature: when inhibition, neuromodulation, disease, and cross-species comparison are deliberately set aside, what does the record of excitatory-to-excitatory (E→E) wiring and dynamics actually establish — at the level of anatomy, of physiology, and of the computational accounts that have been built on top of it? The construct under scrutiny...content/01_introduction.md:line 6Open reference}9, into whisking-modulated and non-modulated subsets in S1 ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}0, and...

• ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}1 A worked example will recur. The Ntsr1-Cre line provides genetic access to L6 corticothalamic neurons and was characterised as a projection-class identifier with high specificity ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}2. Awake recordings, however, split the Ntsr1-Cre+ population into sensory-activated and sensory-suppressed channels in V1 ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}3, into whisking-modulated and non-modulated subsets in S1 ^{9Citationpaper:paper-89006181f9d5The mouse-cortex literature already commits to a projection-class taxonomy adopted here without modification. Pyramidal neurons partition into intratelencephalic (IT) cells with cortico-cortical and cortico-striatal projections, pyramidal-tract (PT) cells with subcortical targets (corticospinal, corticotectal, corticopontine), and corticothalamic (CT) cells [Tantirigama2016, Anderson2010]. These classes are accessed...content/01_introduction.md:line 10Open reference}4, and...