- claim_text
After monocular enucleation in mice, Rbp4-Cre+ layer 5 cortical axons from putative primary visual cortex aberrantly innervate the dLGN — an originally L6-only target — indicating that the L5 PT vs L6 CT segregation by thalamic target is not hard-wired but can be reorganized by sensory deprivation.
- raw_fields
{
"n": null,
"doi": "10.1002/cne.25304",
"claim": "After monocular enucleation in mice, Rbp4-Cre+ layer 5 cortical axons from putative primary visual cortex aberrantly innervate the dLGN — an originally L6-only target — indicating that the L5 PT vs L6 CT segregation by thalamic target is not hard-wired but can be reorganized by sensory deprivation.",
"cite_key": "Giasafaki2022",
"evidence": "Combined Cre-dependent anterograde tracing and immunohistochemistry in Rbp4-Cre mice after neonatal monocular enucleation.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse visual cortex (V1) layer 5, Rbp4-Cre line, neonatal monocular enucleation",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "Comparisons with developmental gene expression patters in dLGN suggest more immature and delayed gene expression in enucleated dLGN. Combined tracing and immuno-histochemical analysis revealed that the induced layer 5 fibers that innervate enucleated dLGN originate from putative primary visual cortex and they retain increased VGluT1+ synapse formation into adulthood.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-f353a07741e4"
]
- source_span
Comparisons with developmental gene expression patters in dLGN suggest more immature and delayed gene expression in enucleated dLGN. Combined tracing and immuno-histochemical analysis revealed that the induced layer 5 fibers that innervate enucleated dLGN originate from putative primary visual cortex and they retain increased VGluT1+ synapse formation into adulthood.
- evidence_refs
[
{
"ref": "paper:paper-f353a07741e4"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}