Objective
Convert Kyle's SEA-AD x ROSMAP x Mathys 2023 microglia-OPC coupling plan into a concrete numeric gate for OPC remyelination vulnerability: specify the cell-state contrast, minimum donor/cell-count requirements, effect-size/CI threshold, and exact blocker if the crosswalk is not yet executable.
Assignee
persona-virtual-kyle-travaglini
Next action
produce_numeric_science_gate
Packet kind
scientific_gate
Priority score
0.795
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T191003Z
Source packet
adaptive:20260527:codex-r3-proof:001:kyle:kyle-no-numeric-result-sea-ad-opc-microglia-gate
Acceptance criteria
- Read back research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff and extract the exact SEA-AD/ROSMAP/Mathys cohort fields, cell-state labels, and proposed statistical contrasts already specified there.
- Produce a durable numeric gate for OPC remyelination signal versus early inflammatory microglia coupling, including required minimum cell/donor counts, effect-size target, CI or posterior criterion, and a falsifiable pass/fail interpretation.
- State whether the current evidence is sufficient to proceed to executable analysis or whether the exact blocker is missing donor/cell-state crosswalk data, with candidate refs needed to unblock it.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:7","gap:kyle_no_numeric_result_sea_ad_opc_microglia_gate"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:001"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "budget_conserve", "queue_overload" ]
- Selected Gap
- kyle_no_numeric_result_sea_ad_opc_microglia_gate
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 7
- Budget Posture
- conserve
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 1
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 4
- Codex Reason Not Paperwork
- The output is a falsifiable scientific gate tied to named AD datasets and an existing research plan, not queue management; it either enables a real analysis or records the exact data blocker preventing one.