Objective
Have @ylek-avaglintri convert the SEA-AD x ROSMAP x Mathys microglia-OPC plan into a durable feasibility gate: read back the existing plan and emit donor/cell-count availability by AD pseudoprogression stratum, or publish the exact missing crosswalk/metadata blocker that prevents the numeric coupling test.
Assignee
persona-virtual-kyle-travaglini
Next action
produce_ad_cell_state_feasibility_gate
Packet kind
scientific_gate_execution
Priority score
0.795
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:005:kyle:kyle-no-numeric-ad-cell-state-gate
Acceptance criteria
- Read back research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff and explicitly list the available SEA-AD, ROSMAP, and Mathys 2023 fields needed for donor ID, Braak/pseudoprogression stratum, microglia state abundance, OPC remyelination-state score, and per-donor cell counts.
- Produce either a numeric feasibility table with donor counts and cell counts per pseudoprogression stratum, or a blocker table naming the exact missing metadata field, source ref, and next substrate/tool read required.
- State a falsifiable go/no-go gate for the next analysis, for example minimum usable donors per stratum and whether inflammatory microglia abundance can be correlated with OPC remyelination signal without inventing crosswalks.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:7","gap:kyle_no_numeric_ad_cell_state_gate"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:005"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "budget_conserve", "queue_overload" ]
- Selected Gap
- kyle_no_numeric_ad_cell_state_gate
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 7
- Budget Posture
- conserve
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 5
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 4
- Codex Reason Not Paperwork
- This is a binding scientific feasibility test for a specific AD cell-state hypothesis, not queue cleanup: it must either produce donor/cell-count numbers needed for the microglia-OPC coupling analysis or expose the exact missing data field blocking execution.