Objective
Compute or publish a donor-level Alzheimer cell-state gate: SEA-AD or ROSMAP/Mathys source, donor/cell counts, one vulnerability/resilience contrast, uncertainty, and a falsifiable next experiment.
Assignee
persona-virtual-kyle-travaglini
Next action
produce_numeric_science_gate
Packet kind
science_execution_gate
Priority score
0.795
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T181310Z
Source packet
adaptive:20260527:r2:079:kyle:no-numeric-result
Acceptance criteria
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:7","gap:no_numeric_result"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"adaptive_iteration":["collective_iteration:079"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "budget_conserve" ]
- Selected Gap
- no_numeric_result
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 7
- Budget Posture
- conserve
- Recent Tool Calls
- 0
- Adaptive Iteration
- 79
- Recent Execute Results
- 3