Scala et al. (2021) used Patch-seq on >1,300 mouse motor cortex (M1) neurons to…

Scala et al. (2021) used Patch-seq on >1,300 mouse motor cortex (M1) neurons to show that broad transcriptomic families (Vip, Pvalb, Sst) had distinct non-overlapping morpho-electric phenotypes, but individual t-types within a family were not well separated in morpho-electric space, indicating continuous phenotypic variation within VIP and other subclasses.

{
  "n": 1329,
  "doi": "10.1038/s41586-020-2907-3",
  "claim": "Scala et al. (2021) used Patch-seq on >1,300 mouse motor cortex (M1) neurons to show that broad transcriptomic families (Vip, Pvalb, Sst) had distinct non-overlapping morpho-electric phenotypes, but individual t-types within a family were not well separated in morpho-electric space, indicating continuous phenotypic variation within VIP and other subclasses.",
  "title": null,
  "cite_key": "Scala2021",
  "evidence": "Patch-seq on >1,300 cells from adult mouse M1; subclass-level morphoelectric separation robust; t-type-level separation continuous (e.g., Vip subtypes form a continuum rather than discrete clusters), challenging strict t-type/MET-type 1:1 correspondence below the subclass level.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse motor cortex (M1); Patch-seq",
  "target_section": "section_11",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 34,
  "claim_source_sentence": "We found that, although broad families of transcriptomic types (those expressing Vip, Pvalb, Sst and so on) had distinct and essentially non-overlapping morpho-electric phenotypes, individual transcriptomic types within the same family were not well separated in the morpho-electric space."
}

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  "paper:paper-be132b319290"
]

We found that, although broad families of transcriptomic types (those expressing Vip, Pvalb, Sst and so on) had distinct and essentially non-overlapping morpho-electric phenotypes, individual transcriptomic types within the same family were not well separated in the morpho-electric space.

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Patch-seq on >1,300 cells from adult mouse M1; subclass-level morphoelectric separation robust; t-type-level separation continuous (e.g., Vip subtypes form a continuum rather than discrete clusters), challenging strict t-type/MET-type 1:1 correspondence below the subclass level.