Details

scope
zebra finch (songbird) Area X (basal ganglia); lentivirus-mediated FoxP2 RNAi
section_id
section_15
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json
effect_size
adult song syllables abnormally variable in acoustic structure and duration
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-15
source_kind
review_finding
source_path
evidence/section_15_evidence_package.json
source_span
Knockdown of FoxP2 resulted in an incomplete and inaccurate imitation of tutor song.
study_system
zebra finch (songbird) Area X (basal ganglia); lentivirus-mediated FoxP2 RNAi
section_title
Species Differences and Evolutionary Scaling of Loop Architecture
evidence_summary
Lentiviral RNAi against FoxP2 was injected into Area X (a basal-ganglia nucleus required for song learning) before zebra finches began song learning; tutor-imitation accuracy and syllable variability were quantified in adulthood.
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-15
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
claim_text
Lentivirus-mediated knockdown of FoxP2 in zebra-finch song-learning nucleus Area X causes incomplete and inaccurate imitation of tutor song with abnormally variable acoustic structure and syllable duration, paralleling features of human FOXP2-related developmental verbal dyspraxia.
raw_fields
{
  "n": 2,
  "doi": "10.1371/journal.pbio.0050321",
  "claim": "Lentivirus-mediated knockdown of FoxP2 in zebra-finch song-learning nucleus Area X causes incomplete and inaccurate imitation of tutor song with abnormally variable acoustic structure and syllable duration, paralleling features of human FOXP2-related developmental verbal dyspraxia.",
  "cite_key": "Haesler2007",
  "evidence": "Lentiviral RNAi against FoxP2 was injected into Area X (a basal-ganglia nucleus required for song learning) before zebra finches began song learning; tutor-imitation accuracy and syllable variability were quantified in adulthood.",
  "effect_size": "adult song syllables abnormally variable in acoustic structure and duration",
  "text_access": "fulltext",
  "study_system": "zebra finch (songbird) Area X (basal ganglia); lentivirus-mediated FoxP2 RNAi",
  "source_cluster_id": "cluster_14",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Knockdown of FoxP2 resulted in an incomplete and inaccurate imitation of tutor song.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The acoustic structure and the duration of adult song syllables were abnormally variable, similar to word production in children with DVD."
}
source_refs
[
  "paper:962eed37-5430-4e42-a2ac-353fbc9e9dfd"
]
evidence_refs
[
  {
    "ref": "paper:962eed37-5430-4e42-a2ac-353fbc9e9dfd"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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