Excitatory-to-excitatory synaptic connections in the mouse C2 barrel column sho…

Excitatory-to-excitatory synaptic connections in the mouse C2 barrel column show layer-dependent short-term plasticity in vitro, with depression dominant at most layer pairs but presynaptic layer-2 neurons giving facilitating excitatory output at 10-30 ms interspike intervals.

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  "n": null,
  "doi": "10.1093/cercor/bhx094",
  "claim": "Excitatory-to-excitatory synaptic connections in the mouse C2 barrel column show layer-dependent short-term plasticity in vitro, with depression dominant at most layer pairs but presynaptic layer-2 neurons giving facilitating excitatory output at 10-30 ms interspike intervals.",
  "cite_key": "Lefort2017",
  "evidence": "Multiple whole-cell paired recordings of synaptically coupled excitatory neurons across layers in acute slices of the mouse C2 barrel column.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse primary somatosensory C2 barrel column, paired whole-cell recording of excitatory neurons",
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  "claim_source_sentence": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections. Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms.",
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We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections. Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms.

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