Human neocortical Patch-seq (n=675 across LAMP5/PAX6=75, VIP=99, SST=149, PVALB…

Human neocortical Patch-seq (n=675 across LAMP5/PAX6=75, VIP=99, SST=149, PVALB=352) demonstrates that the four GABAergic subclasses are separable in UMAP of intrinsic electrophysiological features, with VIP cells displaying diverse morphologies (bipolar dendrites, descending axon) and intrinsic firing ranging from adapting to irregular spiking — consistent with rodent ME-types.

{
  "n": 99,
  "doi": "10.1126/science.adf6484",
  "claim": "Human neocortical Patch-seq (n=675 across LAMP5/PAX6=75, VIP=99, SST=149, PVALB=352) demonstrates that the four GABAergic subclasses are separable in UMAP of intrinsic electrophysiological features, with VIP cells displaying diverse morphologies (bipolar dendrites, descending axon) and intrinsic firing ranging from adapting to irregular spiking — consistent with rodent ME-types.",
  "title": null,
  "cite_key": "Lee2023a",
  "evidence": "Patch-seq from human neurosurgical neocortical tissue (n=675 GABAergic neurons), with morphological reconstruction and transcriptomic mapping",
  "effect_size": "n: LAMP5/PAX6=75, VIP=99, SST=149, PVALB=352; subclasses separable in UMAP of intrinsic ephys features",
  "text_access": "fulltext",
  "study_system": "human neocortex (live surgical tissue) Patch-seq",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 12,
  "claim_source_sentence": "Comprehensive analysis of the associated voltage traces for the four GABAergic subclasses, LAMP5/PAX6 ( n = 75), VIP ( n = 99), SST ( n = 149), and PVALB ( n = 352), revealed distinct passive and active electrophysiological features",
  "replication_evidence_dois": [
    "10.1038/s41586-020-2907-3",
    "10.1016/j.neuron.2021.08.030",
    "10.1038/s41586-021-03465-8"
  ],
  "effect_size_source_sentence": "Comprehensive analysis of the associated voltage traces for the four GABAergic subclasses, LAMP5/PAX6 ( n = 75), VIP ( n = 99), SST ( n = 149), and PVALB ( n = 352), revealed distinct passive and active electrophysiological features"
}

[
  "paper:paper-37824669",
  "paper:paper-430f33cd589f"
]

[
  {
    "ref": "paper:paper-37824669"
  },
  {
    "ref": "paper:paper-430f33cd589f"
  }
]

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  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}