- claim_text
Human PVALB interneurons are more excitable and have larger spatial extent with less neurite branching compared to homologous mouse types, and the SST FRZB type shows gene expression along a continuum of PVALB and SST subclasses but morphoelectric properties aligning with PVALB.
- raw_fields
{
"n": 778,
"doi": "10.1126/science.adf6484",
"claim": "Human PVALB interneurons are more excitable and have larger spatial extent with less neurite branching compared to homologous mouse types, and the SST FRZB type shows gene expression along a continuum of PVALB and SST subclasses but morphoelectric properties aligning with PVALB.",
"evidence": "Patch-seq sampling of 778 human neurons across 44 of 45 GABAergic transcriptomic types using rapid viral genetic labeling in human neurosurgical tissue.",
"effect_size": "778 human neurons sampled across 44/45 GABAergic transcriptomic types",
"text_access": "fulltext",
"study_system": "human neocortex, neurosurgical tissue",
"replication_status": "replication_unknown",
"claim_source_sentence": "We compared the morphoelectric properties of homologous mouse and human neocortical GABAergic neuron types and found that human types are more excitable and have a larger spatial extent with less neurite branching.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Patch-seq sampling facilitated targeted acquisition and analysis of 778 human neurons in cortical layers 2 to 6, across 44 out of 45 GABAergic transcriptomic types."
}- source_refs
[
"paper:paper-37824669",
"paper:paper-430f33cd589f"
]
- evidence_refs
[
{
"ref": "paper:paper-37824669"
},
{
"ref": "paper:paper-430f33cd589f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}