Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

open gaps

#	Title	Status	Priority	Domain	Created
1	What is the therapeutic window for mitophagy enhancement before mitochondrial t… The domain expert identified high safety risks from mitochondrial overactivation but the debate didn't establish safe dosing parameters. This knowledge gap is c… gap-debate-20260410-095938-941d5eec	open	0.850	mitochondrial biology	2026-04-10	Open →
2	How does CHCHD10 dysfunction lead to cristae junction loss and destabilized mit… The authors observe loss of cristae junctions and internal membrane destabilization in motor end plate mitochondria, but the mechanistic link between CHCHD10 mu… gap-pubmed-20260410-181225-84c4a288	open	0.820	mitochondrial biology	2026-04-10	Open →
3	How do mitochondrial haplogroups prevalent in SEA populations affect oxidative… The debate identified this as the most feasible therapeutic target but acknowledged that population-specific mitochondrial dysfunction mechanisms remain unexplo… gap-debate-20260410-111956-49ed8d09	open	0.800	mitochondrial biology	2026-04-10	Open →
4	How do transferred mitochondria integrate functionally with recipient neuron bi… While transfer mechanisms were debated, the critical question of how foreign mitochondria avoid triggering innate immune responses or metabolic disruption in re… gap-debate-20260410-112842-35ab2f9b	open	0.800	mitochondrial biology	2026-04-10	Open →
5	How do MIF and cGAS-STING pathways mechanistically regulate mitophagy in hepati… While the authors identify MIF and cGAS-STING pathways as regulators of mitophagy's impact on HIRI, the specific molecular mechanisms linking these pathways to … gap-pubmed-20260410-181906-5f635fa5	open	0.790	mitochondrial biology	2026-04-10	Open →
6	What determines the temporal sequence between AMPK inhibition and mitochondrial… The study shows both AMPK signaling disruption and abnormal mitochondrial fusion/fission, but the causal relationship and timing between these events is not est… gap-pubmed-20260410-174152-46a8f775	open	0.750	mitochondrial biology	2026-04-10	Open →
7	Can mitochondrial-cytosolic proteostasis coupling be enhanced without disruptin… UPRmt activation was proposed but the debate didn't resolve whether therapeutic enhancement of this pathway would interfere with essential mitochondrial process… gap-debate-20260410-075012-c6f642de	open	0.700	mitochondrial biology	2026-04-10	Open →
8	How do mitochondrial fusion/fission dynamics, biogenesis, and mitophagy differe… While the abstract mentions that mitochondrial fusion/fission, biogenesis, and mitophagy are involved in osteoporosis pathology, the relative contributions and … gap-pubmed-20260410-173057-90d19a0c	open	0.530	mitochondrial biology	2026-04-10	Open →

for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "research_gap",
    "sort": "priority_score_desc",
    "limit": 50
  }
}